Bradley N. Reames
University of Nebraska Medical Center
CancerInternal medicineRadiologySurgeryOncologyLogistic regressionOdds ratioResectionRetrospective cohort studySurvey researchStage (cooking)PancreatitisChemotherapyEsophagectomyToolboxCachexiaResponse rate (survey)Neoadjuvant therapyPancreatectomyPancreasPancreaticoduodenectomyDiseaseComorbidityMEDLINELower riskNADPH oxidaseNOX4Skeletal muscleSurgical oncologyGuidelinePancreatic cancerLeakPancreatic fistulaSterilization (medicine)AdenocarcinomaPancreas surgeryEarly RecurrenceOptimal managementStereotactic radiotherapyInternational surveyStereotactic body radiotherapyLocally advancedCurrent practiceSurgeon volumeCurative resectionOverall survivalLocally advanced pancreatic cancerGastric emptyingPerioperativeConfidence intervalCancer researchRisk factorMedical emergencyDiabetes mellitusGeneral surgerySignal transductionDrainageNetwork formationText miningMedicineCohortDatabaseAnastomosisTranscription factor
Publications 14
#1Bradley N. Reames (UNMC: University of Nebraska Medical Center)H-Index: 3
#1Bradley N. Reames (UNMC: University of Nebraska Medical Center)H-Index: 19
Last. Jin He (Johns Hopkins University)H-Index: 40
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MiniAn international survey of high-volume pancreas cancer surgeons revealed wide variations in management preferences, attitudes regarding contraindications to surgery, and the propensity to offer exploration. When presented with 6 hypothetical clinical vignettes using details from real patients th
14 CitationsSource
#1Alex B. Blair (Johns Hopkins University)H-Index: 17
#2Robert W. KrellH-Index: 17
Last. Bradley N. Reames (UNMC: University of Nebraska Medical Center)H-Index: 3
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BACKGROUND AND PURPOSE There is limited high-level evidence to guide locally advanced pancreas cancer (LAPC) management. Recent work shows that surgeons' preferences in LAPC management vary broadly. We sought to examine whether surgeon volume was associated with attitudes regarding LAPC management. METHODS An electronic survey was distributed by email to an international cohort of pancreas surgeons to evaluate practice patterns regarding LAPC management. Clinical vignette-based questions evaluat...
#1Jeffrey M. Ryckman (WVU: West Virginia University)
#2Bradley N. Reames (UNMC: University of Nebraska Medical Center)H-Index: 3
Last. Lin Chi (UNMC: University of Nebraska Medical Center)
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Abstract Stereotactic Radiotherapy (SRT) over 5-15 days can be interdigitated without delaying chemotherapy. Bridging chemotherapy may allow for extended intervals to surgery, potentially improving sterilization of surgical margins and overall survival. SRT for pancreatic adenocarcinoma should not be limited to the tumor, and should consider hypofractionated approaches to regional nodes.
#1Bradley R. Hall (UNMC: University of Nebraska Medical Center)H-Index: 8
#2Zachary H Egr (UNO: University of Nebraska Omaha)
Last. Bradley N. Reames (UNMC: University of Nebraska Medical Center)H-Index: 3
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The optimal type of operative drainage following pancreaticoduodenectomy (PD) remains unclear. Our objective is to investigate risk associated with closed drainage techniques (passive [gravity] vs. suction) after PD. We assessed operative drainage techniques utilized in patients undergoing PD in the ACS-NSQIP pancreas-targeted database from 2016 to 2018. Using multivariable logistic regression to adjust for characteristics of the patient, procedure, and pancreas, we examined the association betw...
#1Bradley N. Reames (UNMC: University of Nebraska Medical Center)H-Index: 3
#2Flavio G. Rocha (OHSU: Oregon Health & Science University)H-Index: 1
#1Ahmad Hamad (The Ohio State University Wexner Medical Center)H-Index: 2
#2Matthew J. DePuccio (OSU: Ohio State University)H-Index: 4
Last. Aslam Ejaz (OSU: Ohio State University)H-Index: 5
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BACKGROUND The utilization of cancer-directed treatment for patients with all stages of pancreatic cancer in the USA is unknown. This study sought to examine national practice patterns and identify patient, hospital, regional, and other factors associated with disparities in the use of guideline-concordant cancer-directed therapy. METHODS Patients diagnosed with PDAC between 2004 and 2015 were queried from the National Cancer Data Base. Standard of care cancer-directed treatment was defined as s...
#1Bradley N. Reames (UNMC: University of Nebraska Medical Center)H-Index: 19
#1Bradley N. Reames (UNMC: University of Nebraska Medical Center)H-Index: 3
Last. Matthew J. WeissH-Index: 48
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#1Robert W. KrellH-Index: 17
#2Logan R. McNeil (UNMC: University of Nebraska Medical Center)H-Index: 1
Last. Bradley N. Reames (UNMC: University of Nebraska Medical Center)H-Index: 19
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BACKGROUND The use of neoadjuvant therapy (NAT) for pancreatic ductal adenocarcinoma (PDAC) is increasing. While there is an association between NAT and improved post-pancreatectomy complication rates in limited patient populations, the strength of the relationship and its applicability to a broader and modern pancreatectomy cohort remains unclear. METHODS We used the 2014-2018 American College of Surgeons National Surgical Quality Improvement Project to evaluate NAT use for PDAC patients underg...
3 CitationsSource
#1Aneesha Dasgupta (UNMC: University of Nebraska Medical Center)H-Index: 8
#2Surendra K. Shukla (Eppley Institute for Research in Cancer and Allied Diseases)H-Index: 17
Last. Pankaj K. Singh (UNMC: University of Nebraska Medical Center)H-Index: 32
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: Approximately one third of cancer patients die due to complexities related to cachexia. However, the mechanisms of cachexia and the potential therapeutic interventions remain poorly studied. We observed a significant positive correlation between SIRT1 expression and muscle fiber cross-sectional area in pancreatic cancer patients. Rescuing Sirt1 expression by exogenous expression or pharmacological agents reverted cancer cell-induced myotube wasting in culture conditions and mouse models. RNA-s...
7 CitationsSource
#1Bradley N. ReamesH-Index: 3
#1Bradley N. ReamesH-Index: 19
Last. Jin HeH-Index: 40
view all 13 authors...