Juxiong Liu
Jilin University
PhosphorylationInternal medicineEndocrinologyDopaminergicGene expressionProinflammatory cytokineReceptorTight junctionChemistryImmunologyInflammationMicrogliaSubstantia nigrap38 mitogen-activated protein kinasesSignal transductionProtein kinase BBiologyNeuroinflammationCell biologyPharmacology
28Publications
11H-index
381Citations
Publications 28
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#1Wenjin Guo (JLU: Jilin University)H-Index: 10
#2Juxiong Liu (JLU: Jilin University)H-Index: 11
Last. Shoupeng Fu (JLU: Jilin University)H-Index: 19
view all 11 authors...
Long-term intake of a high-fat diet seriously affects the health of pregnant women and leads to increased levels of inflammation in the mammary gland. Therefore, to further explore the effect of a high-fat diet on mammary gland development and the tight junction (TJ) during pregnancy, we placed mice into two groups: a high-fat diet group and a control group. We detected the expression of proteins related to fat synthesis in the mammary gland by western blotting. The results showed that a high-fa...
1 CitationsSource
#1Wenjin Guo (JLU: Jilin University)H-Index: 10
#2Juxiong Liu (JLU: Jilin University)H-Index: 11
Last. Shoupeng Fu (JLU: Jilin University)H-Index: 19
view all 9 authors...
Abstract Oxidative stress consistently affects lactation length and quality in dairy cows. Oxidative stress in the mammary gland of high-yielding dairy cows is a serious problem. Therefore, we studied the role of butyrate in dairy cow oxidative stress and further elucidated the mechanism of the antioxidative action of mammary epithelial cells in dairy cows. Oxidative stress and activated GPR109A were present in high-yielding dairy cows. Then, bovine mammary epithelial cells (BMECs) were isolated...
20 CitationsSource
#1Wenjin Guo (JLU: Jilin University)H-Index: 10
#2Juxiong Liu (JLU: Jilin University)H-Index: 11
Last. Shoupeng Fu (JLU: Jilin University)H-Index: 19
view all 9 authors...
Mastitis is one of three bovine diseases recognized as a cause of substantial economic losses every year throughout the world. Niacin is an important feed additive that is used extensively for dairy cow nutrition. However, the mechanism by which niacin acts on mastitis is not clear. The aim of this study is to investigate the mechanism of niacin in alleviating the inflammatory response of mammary epithelial cells and in anti-mastitis. Mammary glands, milk, and blood samples were collected from m...
2 CitationsSource
#1Dianwen Xu (JLU: Jilin University)H-Index: 5
#2Juxiong Liu (JLU: Jilin University)H-Index: 11
Last. Shoupeng Fu (JLU: Jilin University)H-Index: 19
view all 11 authors...
Abstract Schisandrin A (Sch A), a dibenzocyclooctadiene lignan extracted from Schisandra chinensis (Turcz.) Baill., has anti-oxidant and anti-inflammatory effects, but the effect on masitits has not been studied. Therefore, we investigated the effect of Sch A in cell and mouse models of lipopolysaccharide (LPS)-induced mastitis. Studies in vivo showed that Sch A reduced LPS-induced mammary injury and the production of pro-inflammatory mediators. Sch A also decreased the levels of pro-inflammator...
3 CitationsSource
#1Yancheng Wu (Zhongkai University of Agriculture and Engineering)H-Index: 2
#2Yuhong Gong (JLU: Jilin University)H-Index: 2
Last. Liwei XieH-Index: 14
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Accumulation of amyloid beta (Abeta) peptide, inflammation, and oxidative stress contribute to Alzheimer's disease (AD) and trigger complex pathogenesis. The ketone body beta-hydroxybutyrate (BHBA) is an endogenous metabolic intermediate that protects against stroke and neurodegenerative diseases, but the underlying mechanisms are unclear. The present study aims to elucidate the protective effects of BHBA in the early stage of AD model and investigate the underlying molecular mechanisms. Three-a...
11 CitationsSource
#5Jun Wang (JLU: Jilin University)H-Index: 109
#8Yuhang Li (JLU: Jilin University)H-Index: 8
Previous studies have shown the effects of vitamins on the development of the mammary gland. However, the role of niacin in this process has not been reported. Therefore, the aim of this study was to investigate the effects of niacin on mammary gland development in pubertal mice and to use a mouse mammary epithelial cell line to study the underlying mechanism. The results showed that niacin could activate the AKT/mTOR and ERK signaling pathways by the Gi protein-coupled receptor and increase pho...
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#1Guangxin Chen (Shanxi University)H-Index: 12
#2Bingxu Huang (JLU: Jilin University)H-Index: 13
Last. Juxiong Liu (JLU: Jilin University)H-Index: 11
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The intestinal epithelial barrier is important to mucosal immunity, although how it is maintained after damage is unclear. Here, we show that G protein-coupled receptor 109A (GPR109A) supports barrier integrity and decreases mortality in a mouse cecum ligation and puncture (CLP) sepsis model. Data from 16S RNA sequencing showed that the intestinal microbiota of WT and Gpr109a-/- mice clustered differently and their compositions were disrupted after CLP surgery. GPR109A-deficient mice showed incr...
14 CitationsSource
#1Dewei He (JLU: Jilin University)H-Index: 9
#2Bingxu Huang (JLU: Jilin University)H-Index: 13
Last. Dianfeng Liu (JLU: Jilin University)H-Index: 10
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Parkinson’s disease (PD), a frequent degenerative disease in the elderly, is characterized by dopaminergic neurodegeneration in the substantia nigra pars compacta (SNpc). Neuroinflammation caused by over-activated microglia plays a crucial role in the pathogenesis of PD. Tubeimoside I (TBMS1) has a broad anti-inflammatory effect in peripheral tissues, but the effect on neuroinflammation has not been reported. Therefore, we explored whether TBMS1 could protect dopaminergic neurons by inhibiting t...
14 CitationsSource
#1Bingxu Huang (JLU: Jilin University)H-Index: 13
#2Juxiong Liu (JLU: Jilin University)H-Index: 11
Last. Shoupeng Fu (JLU: Jilin University)H-Index: 19
view all 6 authors...
Abstract Myricetin, one of the lipophenolic compounds present in red wine, has been reported to pass through blood–brain barriers and reduce dopaminergic neuron degeneration, but the mechanism remains unclear. We thoroughly investigated the underlying mechanisms in Parkinson’s disease models both in vivo and in vitro . The neuroprotective effects of myricetin were assessed by performing behavioural test, immunohistochemistry and western blotting in vivo . The expression of pro-inflammatory media...
13 CitationsSource