Elena Landi
National Research Council
Composite numberBiomedical engineeringSolubilityArtificial boneNanotechnologyMaterials scienceMineralogySinteringApatiteBone tissueCarbonateHydroxyapatitesCompressive strengthChemical engineeringPhase (matter)Tissue engineeringThermal stabilityNucleationPorosityScaffold
23Publications
21H-index
3,651Citations
Publications 21
Newest
#1Anna Tampieri (National Research Council)H-Index: 53
#2Teresa D'Alessandro (National Research Council)H-Index: 6
Last. José Rivas (University of Santiago de Compostela)H-Index: 70
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Abstract The use of magnetic activation has been proposed to answer the growing need for assisted bone and vascular remodeling during template/scaffold regeneration. With this in mind, a synthesis procedure was developed to prepare bioactive (Fe 2+ /Fe 3+ )-doped hydroxyapatite (Fe-HA), endowed with superparamagnetic-like properties. This new class of magnetic hydroxyapatites can be potentially employed to develop new magnetic ceramic scaffolds with enhanced regenerative properties for bone surg...
164 CitationsSource
#1Anna Tampieri (National Research Council)H-Index: 53
#2Elena Landi (National Research Council)H-Index: 24
Last. M. MarcacciH-Index: 28
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Magnetic bio-hybrid porous scaffolds have been synthesized, nucleating nano-apatite in situ on self-assembling collagen, in the presence of magnetite nano-particles. The magnetic phase acted as a sort of cross-linking agent for the collagen, inducing a chemico-physical-mechanical stabilization of the material and allowing us to control the porosity network of the scaffold. Gradients of bio-mineralization and magnetization were also developed for osteochondral application. The good potentiality o...
80 CitationsSource
#1Nathalie BockH-Index: 11
#2Alberto RiminucciH-Index: 16
Last. Valentin DediuH-Index: 26
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Abstract In recent years, interest in tissue engineering and its solutions has increased considerably. In particular, scaffolds have become fundamental tools in bone graft substitution and are used in combination with a variety of bio-agents. However, a long-standing problem in the use of these conventional scaffolds lies in the impossibility of re-loading the scaffold with the bio-agents after implantation. This work introduces the magnetic scaffold as a conceptually new solution. The magnetic ...
300 CitationsSource
#1Elena Landi (National Research Council)H-Index: 24
#1Elena Landi (National Research Council)H-Index: 21
Last. Anna Tampieri (National Research Council)H-Index: 53
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A cryogenic process, including freeze-casting and drying has been performed to obtain hydroxyapatite (HA) scaffolds (approx. diameter 10 mm, height 20 mm) with completely lamellar morphology due to preferentially aligned channel-like pores. Changing the process parameters that influence the cold transmission efficiency from the bottom to the top of the poured HA slurry, lamellar ice crystals with different thickness grew throughout the samples. After sintering, scaffolds with porosity features n...
134 CitationsSource
#1Anna Tampieri (National Research Council)H-Index: 53
#2Monica Sandri (National Research Council)H-Index: 32
Last. Ivan Martin (University Hospital of Basel)H-Index: 95
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With the ultimate goal to generate suitable materials for the repair of osteochondral defects, in this work we aimed at developing composite osteochondral scaffolds organized in different integrated layers, with features which are biomimetic for articular cartilage and subchondral bone and can differentially support formation of such tissues. A biologically inspired mineralization process was first developed to nucleate Mg-doped hydroxyapatite crystals on type I collagen fibers during their self...
238 CitationsSource
#1Elena Landi (National Research Council)H-Index: 24
#1Elena Landi (National Research Council)H-Index: 21
Last. Anna Tampieri (National Research Council)H-Index: 53
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Abstract Sr and CO 3 co-substituted hydroxyapatite (SrCHA) nanopowder was synthesized by neutralization. The powder was characterized. The improved solubility in Hanks’ balanced solution of SrCHA granules (400–600 μm of dimensional range), potentially usable as bone filler, was assessed and compared with that of an analogous carbonate free granulate. SrCHA porous bodies with interconnected micro- and macro-porosity, which mimic the morphology of spongy bone, were prepared by the impregnation of ...
103 CitationsSource
#1Simone Sprio (National Research Council)H-Index: 26
#2Anna Tampieri (National Research Council)H-Index: 53
Last. Giandomenico Logroscino (Sapienza University of Rome)H-Index: 16
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Abstract Hydroxyapatite powders characterized by ionic substitutions both in anionic and cationic sites were successfully prepared by synthesis in aqueous medium. The process parameters were set up to allow the simultaneous substitution of the foreign ions, namely carbonate, magnesium and silicon in the crystallographic site of calcium and phosphorus, keeping in count the competition which arises between atoms destined to occupy the same crystallographic site. The chemico-physical properties of ...
97 CitationsSource
#1Elena Landi (National Research Council)H-Index: 24
#1Elena Landi (National Research Council)H-Index: 21
Last. Simone Sprio (National Research Council)H-Index: 26
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The incorporation of magnesium ions (in the range 5–10 mol% in respect to Ca) into the hydroxyapatite structure, which is of great interest for the developing of artificial bone, was performed using magnesium chloride, calcium hydroxide and phosphoric acid, as reactants. Among the synthesized powders, the synthetic HA powder containing 5.7% Mg substituting for calcium was selected, due to its better chemico-physical features, and transformed into granules of 400–600 μm, for biocompatibility test...
329 CitationsSource
#1Elena Landi (National Research Council)H-Index: 24
#1Elena Landi (National Research Council)H-Index: 21
Last. Giandomenico Logroscino (Sapienza University of Rome)H-Index: 16
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Abstract Porous apatites, which during resorption can release in situ Sr ions, were prepared to associate an anti-osteoporotic action with the peculiar features of the inorganic phase constituting the bone. Sr-substituted hydroxyapatite (SrHA) powder was directly synthesized using the classical neutralization route, but including Sr ions, and characterized. The higher solubility of SrHA granules of 400–600 μm size, potentially usable as a bone filler, was assessed compared with that of analogous...
221 CitationsSource
#1Luca Bertinetti (UNITO: University of Turin)H-Index: 32
#2Anna Tampieri (Houston Methodist Hospital)H-Index: 53
Last. Gianmario Martra (UNITO: University of Turin)H-Index: 56
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A multi-technique study devoted to investigate the surface features of nanosized hydroxyapatite (HA) was carried out. UHR-TEM observation provided evidence that HA nanoparticles are constituted by a crystalline core, elongated in the direction of the crystallographic c-axis, coated by an amorphous layer 1−2 nm thick. By means of IR spectroscopy and microgravimetry, the amount of water and hydroxy groups on the surface was evaluated. For the as-prepared material, it was found that the first hydra...
124 CitationsSource