Abdulaziz Alhussan
University of Victoria
Colloidal goldCancerOncologyNanomedicineSpheroidTumor microenvironmentRadiosensitizerChemotherapyHeLaCisplatinDrug deliveryPancreatic cancerDocetaxelRadiosensitizing AgentCancer researchRadiation therapyClinical trialMonolayerMedicineCancer cell
Publications 3
About half of cancer patients (50%) receive radiotherapy (RT) for the treatment of local tumors. However, one of the main obstacles in RT is the close proximity of adjacent organs at risk, resulting in treatment doses being limited by significant tissue toxicity, hence preventing the necessary dose escalation that would guarantee local control. Effective local cancer therapy is needed to avoid progression of tumors and to decrease the development of systemic metastases which may further increase...
#1Kyle BrommaH-Index: 5
Last. Devika B. ChithraniH-Index: 16
view all 6 authors...
Radiotherapy and chemotherapy are the gold standard for treating patients with cancer in the clinic but, despite modern advances, are limited by normal tissue toxicity. The use of nanomaterials, such as gold nanoparticles (GNPs), to improve radiosensitivity and act as drug delivery systems can mitigate toxicity while increasing deposited tumor dose. To expedite a quicker clinical translation, three-dimensional (3D) tumor spheroid models that can better approximate the tumor environment compared ...
#1Abdulaziz Alhussan (UVic: University of Victoria)
#2Kyle Bromma (UVic: University of Victoria)H-Index: 5
Last. Devika B. Chithrani (UVic: University of Victoria)H-Index: 16
view all 10 authors...
Pancreatic cancer is one of the deadliest with a 5-year survival of 6 to 9%. Nanotechnology offers paradigm-changing opportunity to treat such cancers. Successful integration of nanotechnology into the current paradigm of cancer therapy requires proper understanding of the interface between nanoparticles (NPs) and cancer cells, as well as other key components within the tumor microenvironment (TME), such as normal fibroblasts (FBs) and cancer-associated FBs (CAFs). So far, much focus has been on...