Ece Pinar Demirci Bozdogan
University of Victoria
Colloidal goldCancerInternal medicineOncologyTumor microenvironmentChemotherapyCisplatinPancreatic cancerDocetaxelCancer RadiotherapyRadiosensitizing AgentCancer therapyTumor growthCancer researchRadiation therapyClinical trialMedicineCancer cell
Publications 2
About half of cancer patients (50%) receive radiotherapy (RT) for the treatment of local tumors. However, one of the main obstacles in RT is the close proximity of adjacent organs at risk, resulting in treatment doses being limited by significant tissue toxicity, hence preventing the necessary dose escalation that would guarantee local control. Effective local cancer therapy is needed to avoid progression of tumors and to decrease the development of systemic metastases which may further increase...
#1Abdulaziz Alhussan (UVic: University of Victoria)
#2Kyle Bromma (UVic: University of Victoria)H-Index: 5
Last. Devika B. Chithrani (UVic: University of Victoria)H-Index: 16
view all 10 authors...
Pancreatic cancer is one of the deadliest with a 5-year survival of 6 to 9%. Nanotechnology offers paradigm-changing opportunity to treat such cancers. Successful integration of nanotechnology into the current paradigm of cancer therapy requires proper understanding of the interface between nanoparticles (NPs) and cancer cells, as well as other key components within the tumor microenvironment (TME), such as normal fibroblasts (FBs) and cancer-associated FBs (CAFs). So far, much focus has been on...