Larry W. Mitcheltree
United States Army Medical Research Institute of Chemical Defense
Internal medicineEndocrinologySurgeryPathologyChemistryIn vivoSystemic administrationNeurogenic inflammationMechanism of actionChemotherapyCorticosteroidInhalationDermisErythemaHairlessIndometacinSulfur mustardEpidermisEdemaFilter paperEpidermal necrosisNiacinamideMicrovesicleToxicityFirst world warLung injuryBiochemical mechanismNecrosisStereochemistryMedicineNAD+ kinasePharmacology
5Publications
4H-index
207Citations
Publications 5
Newest
May 1, 2010 in ATS (American Thoracic Society International Conference)
#1Dana R. AndersonH-Index: 25
#2Michele L. Conti (DA: United States Department of the Army)H-Index: 5
Last. Wesley W. Holmes (University of Colorado Denver)H-Index: 11
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#1Dana R. Anderson (United States Army Medical Research Institute of Chemical Defense)H-Index: 25
#2Larry W. Mitcheltree (United States Army Medical Research Institute of Chemical Defense)H-Index: 4
Last. Mark B. Gold (United States Army Medical Research Institute of Chemical Defense)H-Index: 4
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Sulfur mustard (HD) is a vesicant compound that was first used as a chemical warfare agent in World War I. (Papirmeister et al. 1991). Numerous animal models have been used to study HD-induced vesication. In this article, we describe modifications of the vapor cup model of Mershon and colleagues (1990) to establish a new vapor cup model for use in neonatal mice. The need to develop this model resulted from the development of gene-targeted knockout mice that can be used to evaluate the function o...
4 CitationsSource
#1Michael C. Babin (United States Army Medical Research Institute of Chemical Defense)H-Index: 12
#2Karen M. Ricketts (United States Army Medical Research Institute of Chemical Defense)H-Index: 6
Last. Robert P. Casillas (United States Army Medical Research Institute of Chemical Defense)H-Index: 20
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The mouse ear vesicant model (MEVM) provides a quantitative edema response as well as histopathological and biochemical endpoints as measurements of inflammation and tissue damage following exposure to the chemical warfare agent sulfur mustard (HD). In the MEVM, several topically applied anti-inflammatory agents provided a significant degree of protection against HD-induced edema and dermal-epidermal separation. This study evaluated the protective effects of three of these pharmacological compou...
75 CitationsSource
#1Robert P. Casillas (United States Army Medical Research Institute of Chemical Defense)H-Index: 20
#2Robyn C. Kiser (Battelle Memorial Institute)H-Index: 9
Last. James A. Blank (Battelle Memorial Institute)H-Index: 6
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The mouse ear edema model is recognized for its usefulness in studying skin responses and damage following exposure to chemical irritants, and for evaluating pharmacological agents against chemically induced skin injury. We recently modified the mouse ear edema model for use with sulfur mustard (HD) and used this model to study the protective effect of 33 topically applied compounds comprising five pharmaceutical strategies (anti-inflammatories, protease inhibitors, scavengers/chelators, poly(AD...
102 CitationsSource
#1Jeffrey J. Yourick (United States Army Medical Research Institute of Chemical Defense)H-Index: 1
#1Jeffrey J. Yourick (United States Army Medical Research Institute of Chemical Defense)H-Index: 5
Last. Larry W. Mitcheltree (United States Army Medical Research Institute of Chemical Defense)H-Index: 12
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It has been proposed that sulfur mustard (HD) may indirectly activate poly(ADP-ribose) polymerase (PADPRP) by alkylating cellular DNA (Papirmeister et al., 1985). Activation of PADPRP results in the depletion of cellular NAD+, which initiates a series of biochemical processes that have been proposed to culminate in blister formation. Preventing PADPRP activation and NAD+ depletion should inhibit blister formation. Niacinamide is both an inhibitor of PADPRP and a precursor for NAD+ synthesis. The...
65 CitationsSource