Rofaida Salem
Kafrelsheikh University
SelectivityCancerMolecular descriptorMolecular modelPoly ADP ribose polymeraseChemistryApoptosisLipophilicityCarbohydrazideCarbonic anhydraseBenzofuranIsatinIC50UreaCancer cell linesNormal phaseChromatographyCancer researchGene isoformStereochemistryCell culture
Publications 3
#1Wagdy M. Eldehna (Kafrelsheikh University)H-Index: 25
#2Rofaida Salem (Kafrelsheikh University)H-Index: 1
Last. Hatem A. Abdel-AzizH-Index: 32
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In the current work, a new set of carbohydrazide linked benzofuran-isatin conjugates (5a-e and 7a-i) was designed and synthesised. The anticancer activity for compounds (5b-d, 7a, 7b, 7d and 7g) was measured against NCI-55 human cancer cell lines. Compound 5d was the most efficient, and thus subjected to the five-dose screen where it showed excellent broad activity against almost all tested cancer subpanels. Furthermore, all conjugates (5a-e and 7a-i) showed a good anti-proliferative activity to...
#1Moataz A. Shaldam (Kafrelsheikh University)H-Index: 4
#2Wagdy M. Eldehna (Kafrelsheikh University)H-Index: 25
Last. Claudiu T. Supuran (UniFI: University of Florence)H-Index: 152
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Abstract In the present study, we describe the design of different series of benzofuran-based derivatives as potential carbonic anhydrase inhibitors (CAIs). The adopted design is based on bioisosteric replacement for the p-fluorophenyl SLC-0111 tail with the lipophilic 2-methylbenzofuran or 5-bromobenzofuran tails to furnish the 2-methylbenzofuran (MBF) sulfonamides (MBFS; 9, 11 and 13) and 5-bromobenzofuran (BBF) sulfonamides (BBFS; 27a-b, 28a-b and 29a-c), respectively. Thereafter, the urea sp...
7 CitationsSource
#1Ahmed F. Abdel Hakiem (Kafrelsheikh University)H-Index: 3
#2Ahmed Kamal (Assiut University)H-Index: 3
Last. Ahmed S. Aboraia (Assiut University)H-Index: 9
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The chromatographic analysis of a number of β-blockers on different thin-layer chromatography (TLC) systems was carried out. The analysis was done on three different systems, namely normal phase, p...