Figueroa T
École nationale vétérinaire de Toulouse
Host (biology)Innate immune systemVirologyImmunologyInterferonLungHamsterHemagglutinin (influenza)DiseasePathogenesisLow pathogenicTiterRecombinant DNAInfluenza A virus subtype H5N1Weight lossMedicineNasal administrationBiologyViral evolutionCompetition (biology)
2Publications
2H-index
1Citations
Publications 7
Newest
#1Cynthia Calzas (Université Paris-Saclay)H-Index: 2
#2Molida Mao (Université Paris-Saclay)
Last. Pierre-Louis Hervé (Université Paris-Saclay)
view all 16 authors...
Current inactivated vaccines against influenza A viruses (IAV) mainly induce immune responses against highly variable epitopes across strains and are mostly delivered parenterally, limiting the development of an effective mucosal immunity. In this study, we evaluated the potential of intranasal formulations incorporating conserved IAV epitopes, namely the long alpha helix (LAH) of the stalk domain of hemagglutinin and three tandem repeats of the ectodomain of the matrix protein 2 (3M2e), as univ...
Source
#1G. Dupre (École nationale vétérinaire de Toulouse)
#2Claire HoedeH-Index: 13
Last. Romain Volmer (École nationale vétérinaire de Toulouse)H-Index: 8
view all 8 authors...
Source
#1P. Bessiere (École nationale vétérinaire de Toulouse)H-Index: 2
#2Figueroa T (École nationale vétérinaire de Toulouse)H-Index: 2
Last. Romain Volmer (École nationale vétérinaire de Toulouse)H-Index: 8
view all 10 authors...
Highly pathogenic avian influenza viruses (HPAIV) emerge from low pathogenic avian influenza viruses (LPAIV) through the introduction of basic amino acids at the hemagglutinin (HA) cleavage site. Following viral evolution, the newly formed HPAIV likely represents a minority variant within the index host, predominantly infected with the LPAIV precursor. Using reverse-genetics engineered H5N8 viruses differing solely at the HA cleavage, we tested the hypothesis that the interaction between the min...
Source
#1P. Bessiere (École nationale vétérinaire de Toulouse)H-Index: 2
#2M. Wasniewski (ANSES)H-Index: 7
Last. Nathan Cebron (École nationale vétérinaire de Toulouse)H-Index: 2
view all 16 authors...
Impaired type I interferons (IFNs) production or signaling have been associated with severe COVID-19, further promoting the evaluation of recombinant type I IFNs as therapeutics against SARS-CoV-2 infection. In the Syrian hamster model, we show that intranasal administration of IFN-α starting one day pre-infection or one day post-infection limited weight loss and decreased viral lung titers. By contrast, intranasal administration of IFN-α starting at the onset of symptoms three days post-infecti...
Source
#1P. Bessiere (École nationale vétérinaire de Toulouse)H-Index: 2
#2Figueroa T (École nationale vétérinaire de Toulouse)H-Index: 2
Last. Romain Volmer (École nationale vétérinaire de Toulouse)H-Index: 8
view all 10 authors...
Highly pathogenic avian influenza viruses (HPAIV) emerge from low pathogenic avian influenza viruses (LPAIV) through the introduction of basic amino acids at the hemagglutinin (HA) cleavage site. Following viral evolution, the newly formed HPAIV likely represents a minority variant within the index host, predominantly infected with the LPAIV precursor. Using reverse-genetics engineered H5N8 viruses differing solely at the HA cleavage, we tested the hypothesis that the interaction between the min...
Source
#1P. Bessiere (École nationale vétérinaire de Toulouse)H-Index: 2
#4C. Foret-LucasH-Index: 2
Last. Romain VolmerH-Index: 8
view all 9 authors...
Highly pathogenic avian influenza viruses (HPAIV) emerge from low pathogenic avian influenza viruses (LPAIV) through the introduction of basic amino acids at the hemagglutinin (HA) cleavage site. Following viral evolution, the newly formed HPAIV likely represents a minority variant within the index host, predominantly infected with the LPAIV precursor. Using reverse-genetics engineered H5N8 viruses differing solely at the HA cleavage, we tested the hypothesis that the interaction between the min...
Source
#1P. Bessiere (École nationale vétérinaire de Toulouse)H-Index: 2
#2Marine Wasniewsk (ANSES)H-Index: 1
Last. Romain Volmer (École nationale vétérinaire de Toulouse)H-Index: 8
view all 16 authors...
Impaired type I interferons (IFNs) production or signaling have been associated with severe COVID-19, further promoting the evaluation of recombinant type I IFNs as therapeutics against SARS-CoV-2 infection. In the Syrian hamster model, we show that intranasal administration of IFN- starting one day pre-infection or one day post-infection limited weight loss and decreased viral lung titers. By contrast, intranasal administration of IFN- starting at the onset of symptoms three days post-infection...
Source
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