Matteo Calligaris
ISMETT
Matrix metalloproteinaseTumor necrosis factor alphaIn vivoTransmembrane proteinDisintegrinDiseaseContext (language use)Computational biologyBiologyImmune system
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#2Doretta Cuffaro (UniPi: University of Pisa)H-Index: 5
Last. Simone D. Scilabra (ISMETT)H-Index: 8
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For decades, disintegrin and metalloproteinase 17 (ADAM17) has been the object of deep investigation. Since its discovery as the tumor necrosis factor convertase, it has been considered a major drug target, especially in the context of inflammatory diseases and cancer. Nevertheless, the development of drugs targeting ADAM17 has been harder than expected. This has generally been due to its multifunctionality, with over 80 different transmembrane proteins other than tumor necrosis factor α (TNF) b...
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