Alyn H. Morice
Hull York Medical School
Binding siteTonicityMutantMolecular biologyTransient receptor potential channelPhagocytosisMutagenesisHEK 293 cellsAnkyrinChemistryCalcium signalingImmunologyTHP1 cell lineStimulationCD163Respiratory diseaseFlufenamic acidChronic coughAlveolar macrophageImmunofluorescenceCD80CD14MacrophageRhinovirusCD11cUpper respiratory tract infectionLung alveolusCluster of differentiationFlow cytometryStereochemistryMedicineIntracellularA549 cellCell cultureTRPV4Cell biologyPharmacology
5Publications
2H-index
15Citations
Publications 5
Newest
#1Samantha K. Atkinson (Hull York Medical School)H-Index: 2
#2Alyn H. Morice (Hull York Medical School)H-Index: 2
Last. Laura R. Sadofsky (Hull York Medical School)H-Index: 12
view all 3 authors...
Human rhinovirus (RV) is the most common cause of upper respiratory tract infection (URTI) and chronic airway disease exacerbation. Cough is present in 50–80% of URTI cases, accompanied by heightened airway hypersensitivity, yet no effective treatment currently exists for this infectious cough. The mechanism by which RV causes cough and airway hypersensitivity in URTI is still unknown despite recent advances in potential therapies for chronic cough. The effect of RV-16 infection (MOI 1) on intra...
2 CitationsSource
#1Laura R. Sadofsky (Hull York Medical School)H-Index: 12
#2Yvette A. Hayman (Hull York Medical School)H-Index: 3
Last. Alyn H. Morice (Hull York Medical School)H-Index: 2
view all 9 authors...
Purpose There is currently no true macrophage cell line and in vitro experiments requiring these cells currently require mitogenic stimulation of a macrophage precursor cell line (THP-1) or ex vivo maturation of circulating primary monocytes. In this study, we characterise a human macrophage cell line, derived from THP-1 cells, and compare its phenotype to the THP-1 cells.
1 CitationsSource
#1Arundhasa Chandrabalan (Hull York Medical School)H-Index: 1
#2Martin J. McPhillie (University of Leeds)H-Index: 7
Last. Laura R. Sadofsky (Hull York Medical School)H-Index: 12
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The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel, which detects noxious stimuli leading to pain, itch and cough. However, the mechanism(s) of channel modulation by many of the known, non-reactive modulators has not been fully elucidated. N-cinnamoylanthranilic acid derivatives (CADs) contain structural elements from the TRPA1 modulators cinnamaldehyde and flufenamic acid, so it was hypothesized that specific modulators could be found amongst them and m...
5 CitationsSource
#1Jesse Vance (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 2
#2Andres Santos (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 5
Last. Jorge Cervantes (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 8
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Purpose Diabetes mellitus (DBM) reduces immunological activity and increases susceptibility to various infections, including tuberculosis (TB). Human alveolar macrophage (hAM) functions are altered in DBM.
9 CitationsSource
#1Laura R. Sadofsky (Hull York Medical School)H-Index: 12
#2Yvette A. Hayman (Hull York Medical School)H-Index: 3
Last. Alyn H. Morice (Hull York Medical School)H-Index: 2
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1 CitationsSource