S. Rehberg
Foundation University, Islamabad
Internal medicineCardiac outputSurgeryCardiologyRandomized controlled trialIntensive care medicineHemodynamicsCatecholamineVasopressinMean arterial pressureSeptic shockResuscitationSepsisTerlipressinNorepinephrine (medication)Shock (circulatory)GynecologyAnesthesiaMedicineVasopressin receptor
15Publications
5H-index
119Citations
Publications 15
Newest
#1Gerrit Jansen (FUI: Foundation University, Islamabad)H-Index: 1
#2Nicole Ebeling (FUI: Foundation University, Islamabad)H-Index: 1
Last. Odile Sauzet (Bielefeld University)H-Index: 15
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BACKGROUND: To evaluate the effects of European Resuscitation Council (ERC) COVID-19-guidelines on resuscitation quality emphasizing advanced airway management in out-of-hospital-cardiacarrest. METHODS: In a manikin study paramedics and emergency physicians performed Advanced-Cardiac-Life-Support in three settings: ERC guidelines 2015 (Control), COVID-19-guidelines as suggested with minimum staff (COVID-19-minimal-personnel); COVID-19-guidelines with paramedics and an emergency physician (COVID-...
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#1Tim KampmeierH-Index: 11
Last. Martin WestphalH-Index: 39
view all 6 authors...
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#1Sean S. Scholz (FUI: Foundation University, Islamabad)H-Index: 1
#2Rainer Borgstedt (FUI: Foundation University, Islamabad)H-Index: 1
Last. S. Rehberg (FUI: Foundation University, Islamabad)H-Index: 5
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BACKGROUND Supplementation of vitamin C in septic patients remains controversial despite eight large clinical trials published only in 2020. We aimed to evaluate the evidence on potential effects of vitamin C treatment on mortality in adult septic patients. METHODS Data search included PubMed, Web of Science, and the Cochrane Library. A meta-analysis of eligible peer-reviewed studies was performed in accordance with the PRISMA statement. Only studies with valid classifications of sepsis and intr...
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#1C. ScheerH-Index: 8
#2C FuchsH-Index: 5
Last. Sven-Olaf KuhnH-Index: 10
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Abstract Objectives Sepsis guidelines recommend obtaining blood cultures before starting anti-infective therapy in patients with sepsis. However, little is known of how antibiotic treatment before sampling affects bacterial growth. The aim of this study was to compare the results of blood cultures drawn before and during antibiotic therapy. Methods Prospective clinical cohort study of septic patients. Adult intensive care unit patients with two or three blood culture sets at the beginning of sep...
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Abstract Background Colloid solutions have been associated with kidney dysfunction in septic animals and humans. The present study investigated the influence of resuscitation with human albumin (HA) 5%, hydroxyethyl starch (HES) 130/0.4 6%, and balanced crystalloids on ultrastructural kidney damage, kidney function, and survival in a model of ovine septic shock. Methods After induction of peritoneal septic shock, animals were randomised to one of the following groups: (1) HA 5%, (2) HES 130/0.4 ...
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#1C FuchsH-Index: 5
#2S. WauschkuhnH-Index: 2
Last. Matthias GründlingH-Index: 21
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Abstract Background There is growing evidence that beta-blockade may reduce mortality in selected patients with sepsis. However, it is unclear if a pre-existing, chronic oral beta-blocker therapy should be continued or discontinued during the acute phase of severe sepsis and septic shock. Methods The present secondary analysis of a prospective observational single centre trial compared patient and treatment characteristics, length of stay and mortality rates between adult patients with severe se...
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#1Andrea Morelli (Sapienza University of Rome)H-Index: 46
#2Abele DonatiH-Index: 30
Last. Martin WestphalH-Index: 39
view all 13 authors...
Preclinical and clinical studies report that β-blockers may be an interesting option to attenuate the deleterious effects of prolonged catecholamine exposure during septic shock. Nevertheless, there are concerns that β-blockers may have negative chronotropic and inotropic effects leading to inappropriately low cardiac output. The objective of the present study was therefore to elucidate whether a reduction in heart rate (HR) with esmolol may negatively affect microcirculation in patients with se...
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#1Andrea Morelli (Sapienza University of Rome)H-Index: 46
#2Abele DonatiH-Index: 30
Last. Martin WestphalH-Index: 39
view all 13 authors...
Arginine vasopressin (AVP) and terlipressin (TP) are increasingly used to stabilize mean arterial pressure in the setting of septic shock. Whether these vasopressor agents negatively impact on microcirculatory perfusion is still not fully understood. The objective of the present study was, therefore, to elucidate the effects of AVP and TP on microcirculatory perfusion in patients with catecholamine-dependent septic shock.
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#2Martin WestphalH-Index: 39
Last. Christian ErtmerH-Index: 27
view all 7 authors...
Terlipressin (TP) is increasingly used in catecholamine-dependent septic shock. Whereas recent data suggest advantages of continuous infusion over repetitive bolus infusion, the optimal time of TP initiation remains unclear. The present study was designed as a prospective laboratory experiment to compare the impact of early versus delayed TP infusion on key hemodynamic variables, as well as fluid and catecholamine requirements in ovine septic shock.
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#1Tim-Gerald Kampmeier (WWU: University of Münster)H-Index: 7
#2S. RehbergH-Index: 5
Last. Lange MH-Index: 1
view all 4 authors...
Abstract Arginine vasopressin (AVP) and its synthetic, long-acting analog terlipressin (TP) are potent alternative vasoconstrictors in the treatment of septic patients with catecholamine-refractive vasodilatatory shock. The results from one large randomized clinical trial suggest that AVP plus norepinephrine (NE) infusion is as safe and effective as treatment with NE alone in patients with septic shock. Because the desired effects of vasopressin analogs are basically related to their vasopressin...
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