Kenneth J. Hillan
GeneInternal medicineEndocrinologyPathologyOncologyVascular endothelial growth factor AGene expressionMolecular biologyReceptorTissue microarrayVascular endothelial growth factorBevacizumabAngiogenesisCancer researchCarcinogenesisComputational biologyMedicineIn situ hybridizationBiologyCell biology
Publications 47
#1Aftab Ala (University of Surrey)H-Index: 16
#2David Brown (UCL: University College London)H-Index: 123
Last. Amar P. Dhillon (UCL: University College London)H-Index: 70
view all 11 authors...
Background Enhanced cell expression of MAdCAM-1 is critical in tissue recruitment of lymphocytes in response to stimuli expressing the α4β7 integrin. MAdCAM-1 is well characterized in gut mucosa with emerging evidence of hepatic expression.
11 CitationsSource
#1Adrian M. Jubb (University of Oxford)H-Index: 39
#2Kathy D. MillerH-Index: 71
Last. Hartmut Koeppen (Genentech)H-Index: 58
view all 12 authors...
Purpose: The addition of bevacizumab to cytotoxic chemotherapy has demonstrated a progression-free survival (PFS) benefit in the first-line and second-line treatment of advanced or metastatic breast cancer (MBC). However, the addition of bevacizumab to capecitabine in heavily pretreated MBC patients did not show a PFS benefit (AVF2119g phase III trial). The aim of this study was to evaluate the expression of novel putative biomarkers as predictors of benefit from bevacizumab in retrospective sub...
84 CitationsSource
#1Brock A. Peters (Genentech)H-Index: 23
#2Zhengyan Kan (Genentech)H-Index: 23
Last. Somasekar Seshagiri (Genentech)H-Index: 61
view all 18 authors...
The discovery of somatic mutations in cancer tissue is extremely laborious, time-consuming and costly. In an evaluation comparing mismatch repair detection (MRD) against Sanger sequencing for somatic-mutation detection, we found that MRD had a specificity of 96% and a sensitivity of 92%. Our results showed that MRD is a robust and cost-effective alternative to Sanger sequencing for identifying somatic mutations in human tumors.
8 CitationsSource
#1Adrian M. Jubb (Genentech)H-Index: 39
#2Sreedevi Chalasani (Genentech)H-Index: 7
Last. Hartmut Koeppen (Genentech)H-Index: 58
view all 10 authors...
Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia
122 CitationsSource
#1M. G. Scott ('QUB': Queen's University Belfast)H-Index: 13
#2W. Glenn McCluggageH-Index: 60
Last. S. E. Hilary Russell ('QUB': Queen's University Belfast)H-Index: 16
view all 5 authors...
Ovarian carcinoma represents the most lethal gynaecological malignancy. A variety of morphological subtypes are recognised (e.g. serous, mucinous, endometrioid), which may be benign, borderline or malignant. While their relationship is controversial, knowledge of the molecular mechanisms of ovarian tumorigenesis may help resolve this issue and perhaps identify early markers of disease. Perturbed patterns of expression of the SEPT9 gene on chromosome 17q25.3 have been implicated in a variety of t...
110 CitationsSource
#1Adrian M. Jubb (Genentech)H-Index: 39
#2Herbert HurwitzH-Index: 78
Last. Hartmut KoeppenH-Index: 30
view all 12 authors...
Purpose Bevacizumab is a monoclonal antibody to vascular endothelial growth factor-A (VEGF). In the pivotal trial in metastatic colorectal cancer (mCRC), addition of bevacizumab to first-line irinotecan, fluorouracil, and leucovorin (IFL) significantly prolonged median survival. The aim of these retrospective subset analyses was to evaluate VEGF, thrombospondin-2 (THBS-2), and microvessel density (MVD) as prognostic factors and/or predictors of benefit from bevacizumab. Patients and Methods In t...
505 CitationsSource
#1Adrian M. JubbH-Index: 39
#2Thinh PhamH-Index: 17
Last. Kenneth J. HillanH-Index: 38
view all 5 authors...
: Tissue microarrays enable the rapid histological localization of gene expression in hundreds of archival samples by in situ hybridization. However, the scoring of tissue microarray data may be influenced by intra- and inter-observer variations, and categorizing continuous variables risks discarding potentially meaningful information. Quantitation imposes a greater degree of objectivity, is more reproducible than subjective discriminations, and facilitates the communication and clarity of defin...
14 CitationsSource
#1Peter A. Hall ('QUB': Queen's University Belfast)H-Index: 25
#2C. B. ToddH-Index: 1
Last. S. E. Hilary RussellH-Index: 16
view all 8 authors...
Anillin is an actin-binding protein that can bind septins and is a component of the cytokinetic ring. We assessed the anillin expression in 7,579 human tissue samples and cell lines by DNA microarray analysis. Anillin is expressed ubiquitously but with variable levels of expression, being highest in the central nervous system. The median level of anillin mRNA expression was higher in tumors than normal tissues (median fold increase 2.58; 95% confidence intervals, 2.19-5.68, P r ∼ 0.6, P
89 CitationsSource
#1David A. Eberhard (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 21
#2Bruce E. Johnson (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 124
Last. Kenneth J. Hillan (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 38
view all 19 authors...
Purpose Epidermal growth factor receptor (EGFR) mutations have been associated with tumor response to treatment with single-agent EGFR inhibitors in patients with relapsed non–small-cell lung cancer (NSCLC). The implications of EGFR mutations in patients treated with EGFR inhibitors plus first-line chemotherapy are unknown. KRAS is frequently activated in NSCLC. The relationship of KRAS mutations to outcome after EGFR inhibitor treatment has not been described. Patients and Methods Previously un...
2,057 CitationsSource