Chaoyue Yang
Jilin University
Cell cycle checkpointmicroRNAEndoplasmic reticulumGene knockdownKinaseChemistryCyclin D1Oxidative stressI?BaAllicinCell cycleReactive oxygen speciesp38 mitogen-activated protein kinasesMAPK/ERK pathwayCell growthSignal transductionCell biologyEctopic expression
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#1Yuan Yuan (JLU: Jilin University)H-Index: 10
#2Ziyue Wang (JLU: Jilin University)H-Index: 1
Last. Haiyang Yan (JLU: Jilin University)H-Index: 1
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Furan is a genotoxic and carcinogenic toxicant formed during the food thermal processing. Our previous studies confirmed that salidroside (SAL) displayed excellent protective effects against furan-induced hepatotoxicity and inflammation, whereas the underlying mechanism was still unclear. In the current study, Balb/c mice were divided to the control group (CON), the furan model group (FUR8, 8 mg/kg BW furan for 30 days) and SAL intervention groups (SAL10/20/40, 8 mg/kg BW furan for 30 days + 10/...
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#1Chaoyue Yang (JLU: Jilin University)
#2Bo Nan (JLU: Jilin University)H-Index: 2
Last. Yuan Yuan (JLU: Jilin University)H-Index: 10
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Abstract Acrylamide (AA), an important by-product of the Maillard reaction, has been reported to be genotoxic and carcinogenic. The present study employed miRNAs to investigate the toxic mechanism of AA and their role against AA toxicity. Deep sequencing of small RNA libraries was performed and miR-193b-5p was applied for further study. AA significantly reduced the level of miR-193b-5p and its ectopic expression promoted cell cycle G1/S transition and cell proliferation by upregulating the cycli...
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#1Bo Nan (JLU: Jilin University)H-Index: 2
#2Chaoyue Yang (JLU: Jilin University)
Last. Yuan Yuan (JLU: Jilin University)H-Index: 10
view all 7 authors...
Abstract Acrylamide (AA) in heat-processed food leads to widespread concerns due to its hepatotoxicity. Allicin, a plant-derived antioxidant, possesses a significant protective effect on AA-induced hepatotoxicity, but the mechanism is still unclear. Herein, we investigated the mechanism in Kupffer cells and SD rats liver. Molecular docking, molecular dynamics simulation and LigPlus software speculated that allicin inhibited the activity of CYP2E1 expression by binding to its amino acid residues ...
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