Yunhui Fan
Internal medicineDownregulation and upregulationEndocrinologyLipolysisAdipose tissueKinaseChemistryApoptosisCyclin-dependent kinase 6AutophagySuperoxide dismutaseTLR4Oxidative stressAdipocyteKEAP1Liver injuryInflammationNFE2L2AntioxidantMalondialdehydeAlanine transaminaseAcetaminophenSteatohepatitisAMPKHMGB1Retinoic acidAloinSequestosome 1Liver functionReactive oxygen speciesGlutathionePharmacology
4Publications
2H-index
0Citations
Publications 4
Newest
#1Qiushi XuH-Index: 3
#2Yunhui FanH-Index: 2
Last. Chuang XuH-Index: 8
view all 8 authors...
ABSTRACT Adipose tissue concentration of reactive oxygen species (ROS) increases in dairy cows with ketosis, suggesting that the tissue experiences oxidative stress. Autophagy, an adaptive response to cellular stress, has been shown to promote survival and plays a critical role in antioxidant responses. Dysregulation of adenosine 5′-monophosphate-activated protein kinase (AMPK) is closely related to antioxidant responses and autophagy of adipocytes in animal models of metabolic disorders, but it...
Source
#1Qiushi XuH-Index: 3
#2Yunhui FanH-Index: 2
Last. Chuang XuH-Index: 8
view all 8 authors...
ABSTRACT Preadipocyte proliferation and differentiation are critical for normal adipose tissue development, including achieving a mature phenotype, characterized by its ability to accumulate triacylglycerol and release fatty acids. In nonruminants, it is well known that all-trans retinoic acid (ATRA), the most-active form of vitamin A, helps regulate proliferation, differentiation, and apoptosis in several types of cells including adipocytes. The purpose of this study was to evaluate the effect ...
Source
#1Qiushi XuH-Index: 3
#2Yunhui FanH-Index: 2
Last. Chuang XuH-Index: 8
view all 8 authors...
Aloin, a naturally occurring anthraquinone glycoside derived from the Aloe species, has antioxidant and anti-inflammatory activities, but its role in non-alcoholic steatohepatitis (NASH) remains unknown. This study was designed to investigate the anti-inflammatory, antioxidant, and anti-apoptotic effects of aloin and the underlying mechanisms during NASH. Wild-type or nuclear erythroid 2–related factor 2 (Nrf2) knock-out (KO) mice were fed a choline-deficient, L-amino acid-defined, high-fat (CDA...
Source
#1Qiushi XuH-Index: 3
#2Yunhui FanH-Index: 2
Last. Chuang XuH-Index: 8
view all 8 authors...
Cardamonin (CD), a naturally occurring chalcone derived from the Alpinia species, has been shown to exert antioxidant and anti-inflammatory activity, but its role in the prevention of acetaminophen (APAP)-induced hepatotoxicity remains elusive. The objective of this study was to determine the protective effects of CD against APAP-induced acute liver injury (ALI) and the underlying mechanisms. Wild-type (WT) or transcription factor nuclear factor erythroid 2-related factor 2 (NFE2L2)-deficient mi...
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