Hao Li
Nankai University
Regenerative medicineClonogenic assayAdipogenesisBiomedical engineeringCell migrationRegeneration (biology)ChemistryExtracellular matrixMesenchymal stem cellProgenitor cellCell sortingHoming (hematopoietic)Drug deliveryCartilageStem cellChondrogenesisTissue engineeringBiologyScaffoldCell biology
13Publications
1H-index
12Citations
Publications 7
Newest
#1Yang Zhen (Chinese PLA General Hospital)H-Index: 1
Last. Quanyi Guo (NKU: Nankai University)H-Index: 27
view all 11 authors...
It remains scientifically challenging to regenerate injured cartilage in orthopedics. Recently, an endogenous cell recruitment strategy based on a combination of acellular scaffolds and chemoattractants to specifically and effectively recruit host cells and promote chondrogenic differentiation has brought new hope for in situ articular cartilage regeneration. In this study, a transforming growth factor-β3 (TGF-β3)-loaded biomimetic natural scaffold based on demineralized cancellous bone (DCB) an...
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#1Kangkang Zha (NKU: Nankai University)H-Index: 2
#2Zhiqiang Sun (NKU: Nankai University)H-Index: 3
Last. Shuyun Liu (Chinese PLA General Hospital)H-Index: 20
view all 10 authors...
Articular cartilage is susceptible to damage, but its self-repair is hindered by its avascular nature. Traditional treatment methods are not able to achieve satisfactory repair effects, and the development of tissue engineering techniques has shed new light on cartilage regeneration. Mesenchymal stem cells (MSCs) are one of the most commonly used seed cells in cartilage tissue engineering. However, MSCs tend to lose their multipotency, and the composition and structure of cartilage-like tissues ...
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#1Kangkang Zha (NKU: Nankai University)H-Index: 2
#2Xu Li (CUHK: The Chinese University of Hong Kong)H-Index: 8
Last. Quanyi Guo (NKU: Nankai University)H-Index: 2
view all 13 authors...
Objectives CD49f is expressed on a variety of stem cells and has certain effects on their cytological functions, such as proliferation and differentiation potential. However, whether CD49f is expressed on the surface of adipose tissue-derived mesenchymal stem cells (ADSCs) and its effect on ADSCs has not been clarified. Materials and methods The effects of in vitro culture passage and inflammatory factor treatment on CD49f expression and the adhesion ability of ADSCs from mice and rats were inve...
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#1Liwei Fu (NKU: Nankai University)H-Index: 1
#1Fu Liwei (Chinese PLA General Hospital)H-Index: 1
Last. Quanyi Guo (NKU: Nankai University)H-Index: 27
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Tissue engineering (TE) has brought new hope for articular cartilage regeneration, as TE can provide structural and functional substitutes for native tissues. The basic elements of TE involve scaffolds, seeded cells, and biochemical and biomechanical stimuli. However, there are some limitations of TE; what most important is that static cell culture on scaffolds cannot simulate the physiological environment required for the development of natural cartilage. Recently, bioreactors have been used to...
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#1Liwei Fu (NKU: Nankai University)H-Index: 1
#2Zhen Yang (NKU: Nankai University)H-Index: 3
Last. Quanyi Guo (NKU: Nankai University)H-Index: 2
view all 9 authors...
Due to the sophisticated hierarchical structure and limited reparability of articular cartilage (AC), the ideal regeneration of AC defects has been a major challenge in the field of regenerative medicine. As defects progress, they often extend from the cartilage layer to the subchondral bone and ultimately lead to osteoarthritis. Tissue engineering techniques bring new hope for AC regeneration. To meet the regenerative requirements of the heterogeneous and layered structure of native AC tissue, ...
3 CitationsSource
#1Hao Li (NKU: Nankai University)H-Index: 1
#2Zhen Yang (NKU: Nankai University)H-Index: 3
Last. Quanyi Guo (NKU: Nankai University)H-Index: 27
view all 10 authors...
The meniscus plays a critical role in maintaining knee joint homeostasis. Injuries to the meniscus, especially considering the limited self-healing capacity of the avascular region, continue to be a challenge and are often treated by (partial) meniscectomy, which has been identified to cause osteoarthritis. Currently, meniscus tissue engineering focuses on providing extracellular matrix (ECM)-mimicking scaffolds to direct the inherent meniscal regeneration process, and it has been found that var...
1 CitationsSource
#1Zhen Yang (NKU: Nankai University)H-Index: 3
#2Hao Li (NKU: Nankai University)H-Index: 1
Last. Quanyi Guo (NKU: Nankai University)H-Index: 27
view all 19 authors...
Injuries to articular cartilage (AC) can lead to cartilage degeneration without timely and proper treatments and ultimately results in osteoarthritis. Regenerative medicine and tissue engineering techniques are emerging as promising approaches for AC regeneration and repair. Typically, AC regenerative medicine and tissue engineering can be divided into two categories, cell-based tissue engineering and cell-homing tissue engineering techniques, based on the involvement of seed cells. Although num...
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