Yasutomo Fujii
Kyoto University
Janus kinaseInternal medicineRadiologyCross-sectional studyUltrasoundChemistryTocilizumabRheumatoid arthritisWristAnkleTofacitinibDiseaseSynovitisAbataceptBelataceptCD86Disease activityRadiographyUltrasonographyMedicineGastroenterologyPharmacology
15Publications
4H-index
34Citations
Publications 14
Newest
#1Hidemasa Matsuo (Kyoto University)H-Index: 9
#2Yuya Tabuchi (Kyoto University)H-Index: 2
Last. Yasutomo Fujii (Kyoto University)H-Index: 4
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PURPOSE This study aimed to evaluate the positive rate and prognostic significance of superb microvascular imaging (SMI) in rheumatoid arthritis (RA) patients in remission with normal C-reactive protein (CRP) levels and erythrocyte sedimentation rates (ESR). METHODS The study enrolled 112 RA patients, and ultrasound (US) assessment was performed on 28 joints of each patient. RESULTS The SMI signal-positive rates for each joint were: metacarpophalangeal (MCP) joints: 20.5%, wrist joints: 43.8%, m...
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#1Shinichiro Ishie (Kyoto University)H-Index: 1
#2Hiromu Ito (Kyoto University)H-Index: 51
Last. Shuichi Matsuda (Kyoto University)H-Index: 64
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OBJECTIVES We aimed to clarify the clinical implication of ultrasound (US)-detected foot joint inflammation in tightly controlled patients with rheumatoid arthritis (RA). METHODS We evaluated bilateral foot joints (second to fifth metatarsophalangeal joints of forefoot; tarsometatarsal, cuneonavicular and midtarsal joints of midfoot) of 430 RA patients for synovitis using Power Doppler (PD) imaging by US. We made a cross-sectional and a 3-year longitudinal analysis about the associations of US-d...
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#1Shuichiro Nakabo (Kyoto University)H-Index: 10
#2Yuko Tsuji (Kyoto University)H-Index: 2
Last. Yasutomo Fujii (Kyoto University)H-Index: 4
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OBJECTIVE: Although recent clinical trials showed that ultrasound (US) remission is not required to achieve good outcomes at the group level, it currently remains unclear whether the prognosis of individual patients in clinical remission, but not US remission, i.e., those with subclinical sonographic synovitis (SSS), is favorable. However, it is no longer acceptable to perform US on all patients in order to identify those with SSS. Therefore, the present study was initiated to elucidate the cond...
1 CitationsSource
#1Takashi Emori (Astellas Pharma)H-Index: 3
#2Michiko Kasahara (Kyoto University)H-Index: 2
Last. Yasutomo Fujii (Astellas Pharma)H-Index: 2
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Abstract Rheumatoid arthritis (RA) fibroblast-like synoviocytes (RA-FLS) play a crucial role in the pathogenesis of RA. RA-FLS display passive pro-inflammatory responses and self-directed aggressive responses, such as pro-inflammatory mediator production, reduced apoptosis and formation of a thickened synovial lining. Evidence suggests a role for Janus kinase (JAK)-signal transducer and transcriptional activator (STAT) signaling in the passive response but the aggressive behavior of RA-FLS is po...
2 CitationsSource
#1Hidemasa Matsuo (Kyoto University)H-Index: 9
#2Akari Imamura (Kyoto University)H-Index: 1
Last. Yasutomo Fujii (Kyoto University)H-Index: 4
view all 11 authors...
Purpose Ultrasound is commonly used to assess the degree of synovitis in patients with rheumatoid arthritis (RA); however, it is unclear which joints are optimal for evaluating and predicting recurrence and remission.
2 CitationsSource
#1Rie Kawahara (Kyoto University)H-Index: 2
#2Shuichiro Nakabo (Kyoto University)H-Index: 10
Last. Yasutomo Fujii (Kyoto University)H-Index: 4
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AbstractObjective: Ultrasonography (US) is a useful tool for evaluating the activity of rheumatoid arthritis (RA) patients. As the systemic evaluation of many joints is time-consuming, a method to ...
1 CitationsSource
#1Hiroko Yamamoto (Kyoto University)H-Index: 2
#2Toshiki Nakajima (Kyoto University)H-Index: 8
Last. Yasutomo Fujii (Kyoto University)H-Index: 4
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AIM: Previous studies have reported that patients with rheumatoid arthritis (RA) have a higher risk of developing cardiovascular disease (CVD) than the general population. A major cause of CVD is atherosclerosis, which can be evaluated with carotid ultrasonography (US). As far as we know, there have been no large-scale carotid artery US studies in Japanese patients with RA. The aim of this study was to identify the risk factors for atherosclerosis in Japanese patients with RA. METHODS: The study...
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#1Tamami Yoshida (Kyoto University)H-Index: 2
#2Motomu Hashimoto (Kyoto University)H-Index: 21
Last. Kazuko Nin (Kyoto University)H-Index: 14
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Rheumatoid arthritis (RA) patients often have altered body composition including reduced muscle mass and increased fat mass. Some RA patients are likely to increase visceral fat without obesity [Body Mass Index (BMI) ≥ 25]. The objective of the study was to determine the association between obesity and/or visceral adiposity and the risk for atherosclerosis in Japanese RA patients. Obesity was evaluated using the BMI, with visceral adiposity evaluated using the visceral fat area (VFA) and the vis...
4 CitationsSource
Background Because elbows are important joints for the function of upper limbs, the daily activity of the patients with rheumatoid arthritis (RA) may be impaired by synovitis of elbows. Although elbows are included into the 28 essential joints for evaluation of the disease activity of RA, ultrasonography (US) examination of elbows is not routinely performed and there have been a few surveys on the correlation between US scores of elbows and disease activity. Objectives To reveal whether there is...
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#1Harumi Koibuchi (Jichi Medical University)H-Index: 9
#2Yasutomo Fujii (Kyoto University)H-Index: 4
Last. Nobuyuki Taniguchi (Jichi Medical University)H-Index: 21
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Purpose The purpose of this study was to clarify the effect of ultrasonic irradiation on biofilm produced by Staphylococcus epidermidis (S. epidermidis), which causes central venous catheter-related infections.
3 CitationsSource