Vincenzo Lagano
GeneCD3Internal medicineOncologyChromatin remodelingCD33Human leukocyte antigenSurgical pathologyIn silicoT cellTumor microenvironmentLung cancerLungMyeloidPopulationLung Neuroendocrine NeoplasmGene mutationCancer researchDNA sequencingMedicineBiology
Publications 2
#1Giovanni CentonzeH-Index: 12
#2Vincenzo LaganoH-Index: 2
Last. Massimo MilioneH-Index: 33
view all 19 authors...
High-grade Gastroenteropancreatic Neuroendocrine neoplasms (H-NENs) comprehend well-differentiated tumors (NET G3) and poorly differentiated carcinomas (NEC) with proliferative activity indexes as mitotic count (MC) >20 mitoses/10 HPF and Ki-67 >20%. At present, no specific therapy for H-NENs exists and the several evidences of microenvironment involvement in their pathogenesis pave the way for tailored therapies. Forty-five consecutive cases, with available information about T-cell, immune, and...
#1Giovanni CentonzeH-Index: 12
#2Davide BiganzoliH-Index: 1
Last. Massimo MilioneH-Index: 33
view all 14 authors...
Lung neuroendocrine neoplasms (LNENs) represent a rare and heterogeneous population of lung tumors. LNENs incidence rate has increased dramatically over the past 30 years. The current World Health Organization LNENs classification (WHO 2015), distinguished four LNENs prognostic categories, according to their morphology, necrosis amount and mitotic count: typical carcinoid (TC), atypical-carcinoid (AC), large cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC). At present, due...
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