R. Murugan
National University of Singapore
Composite numberBiomedical engineeringNuclear chemistryElectrospinningSolubilityComposite materialFourier transform infrared spectroscopyMonomerNanotechnologyChemistryParticle sizeMaterials scienceMineralogyGraftingApatiteBiomaterialDemineralized bone matrixNano-Chemical engineeringTissue engineeringDissolutionScaffoldNanocomposite
Publications 25
#1R. Murugan (NUS: National University of Singapore)H-Index: 16
#2Huang ZmH-Index: 1
Last. Seeram RamakrishnaH-Index: 162
view all 4 authors...
: Scaffold plays a critical role in tissue engineering where it provides necessary structural support for the cells to accommodate and to guide their growth in the three dimensional space into a specific tissue. Therefore, engineering scaffolds favorable for cell/tissue growth is of great importance and a pre-requisite for scaffold-based tissue engineering. Electrospinning is a versatile method that has been recently adapted in engineering nano-fibrous scaffolds that mimic the structural feature...
23 CitationsSource
#1R. Murugan (NUS: National University of Singapore)H-Index: 16
#2Seeram Ramakrishna (NUS: National University of Singapore)H-Index: 162
The sections in this article are Introduction: Problems with Current Therapies Tissue Engineering: A Potential Solution Stem Cells: The Essentials Nanobiomaterials: A New Generation Scaffolding Material Characteristics of Scaffold Types of Scaffolding Materials Ceramic Nanobiomaterials Polymeric Nanobiomaterials Nanofibrous Scaffold Processing: Current Scenarios Self-assembly Phase Separation Electrospinning – A New Approach Experimental System Spinning Mechanism Electrospun Nanofibrous Scaffold...
4 CitationsSource
Demineralized bone factors are capable of stimulating bone regeneration through an osteoinductive mechanism and thus it has been recognized as a good bone graft. In this study, a kind of demineralized bone extracts (DBX) derived from bovine tibia by a chemical route. The extracts thus obtained were analyzed for their bio-chemical and physical properties using various techniques and results provided quite interesting insights into the demineralization process. There is no significant evidence of ...
#1Elizabeth M. Christenson (Rice University)H-Index: 4
#2Kristi S. Anseth (CU: University of Colorado Boulder)H-Index: 124
Last. Antonios G. Mikos (Rice University)H-Index: 153
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Advancements in nanobiotechnology are revolutionizing our capability to understand biological intricacies and resolve biological and medical problems by developing subtle biomimetic techniques. Nanocomposites and nanostructured materials are believed to play a pivotal role in orthopedic research since bone itself is a typical example of a nanocomposite. This article reviews current strategies using nanobiomaterials to improve current orthopedic materials and examines their applications in bone t...
383 CitationsSource
#1R. Murugan (NUS: National University of Singapore)H-Index: 16
#2Seeram Ramakrishna (NUS: National University of Singapore)H-Index: 162
Last. K. Panduranga RaoH-Index: 1
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Abstract A processing method of hydroxy-carbonate apatite (HCAp) from the natural bone and their phase purity, crystal structure, chemical functionality, thermal stability, morphology, and solubility are described in this investigation. The X-ray diffraction analysis suggested that the processed bone corresponds characteristically to carbonate (CO 3 2− ) containing hydroxyapatite. Fourier transform infrared spectroscopic study confirmed the presence of CO 3 2− in addition to hydroxyl (OH − ) and...
157 CitationsSource
#1Casey K. Chan (NUS: National University of Singapore)H-Index: 32
#2T.S. Sampath KumarH-Index: 33
Last. Seeram RamakrishnanH-Index: 1
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Allograft bone, dematerialized bone matrix and calcium-based synthetic materials have long been used as bone graft substitutes. First-generation bone graft substitutes as stand-alone graft substitutes have not developed as hoped. It remains a great challenge to design an ideal bone graft that emulates nature’s own structures or functions. To further improve the performance of such bone graft substitutes, scientists are investigating biomimetic processes to incorporate the desirable nano-features...
96 CitationsSource
Processing bone graft materials that mimic the chemical composition and structure of natural bone is a good option for the treatment of bone defects. This investigation reports a processing condition for the in situ formation of recombinant humanlike collagen-hydroxyapatite (CHA) nanohybrid with chemical composition and crystal structure quite similar to natural bone through bionic approach. The processed CHA was characterized by various physicochemical methods and the results suggested that HA ...
25 CitationsSource
#1R. Murugan (NUS: National University of Singapore)H-Index: 16
#2Seeram Ramakrishna (NUS: National University of Singapore)H-Index: 162
Bovine-derived biological apatite has a long history for use in human health care as bone substitute. This article reports an elegant method of designing bovine-derived hydroxyapatite (BHA) blocks suitable for drug delivery. Neomycin sulphate (NS) was selected as a model drug and its loading and release studies were performed under in-vitro physiological conditions. The results indicate that phase purity and structural integrity of the BHA are retained even after entrapment of drug molecules. It...
10 CitationsSource
#1R. Murugan (NUS: National University of Singapore)H-Index: 16
#2Seeram RamakrishnaH-Index: 162
Tissue engineering is a multidisciplinary field that is rapidly emerging as a promising new approach in the restoration and reconstruction of imperfect tissues. In this approach, scaffolds play a pivotal role in supporting the cells to accommodate and guide their growth into a specific tissue; therefore, designing scaffolds that are favorable to cellular growth is of great importance. Electrospinning is a straightforward, cost-effective, and versatile technique that has been applied recently for...
441 CitationsSource
#1R. Murugan (NUS: National University of Singapore)H-Index: 16
#2Seeram Ramakrishna (NUS: National University of Singapore)H-Index: 162
Abstract Ionic-substituted hydroxyapatite (HAp) based materials may be a better choice than pure HAp owing to their similarity in chemical composition with biological apatite. The present study reports a process for the production of carbonated hydroxyapatite (CHAp) using microwaves. The CHAp was evaluated for its phase purity, chemical homogeneity, functionality, morphology, and solubility. The CHAp thus obtained was compared with a pure HAp and a biological apatite, which provides quite an int...
134 CitationsSource