Anna K. Belford
GeneHypothetical proteinGenomeRefSeqVirologyAntibodyHuman viromeEpitopeCapsidVirus2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Computer scienceRational designGeneticsDNAComputational biologyGenBankBiologyHorizontal gene transfer
7Publications
4H-index
17Citations
Publications 8
Newest
#1Dapeng Sun (University of Pittsburgh)H-Index: 2
#2Zhe Sang (University of Pittsburgh)H-Index: 3
Last. Derek J. Taylor (Case Western Reserve University)H-Index: 18
view all 14 authors...
Interventions against variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are urgently needed. Stable and potent nanobodies (Nbs) that target the receptor binding domain (RBD) of SARS-CoV-2 spike are promising therapeutics. However, it is unknown if Nbs broadly neutralize circulating variants. We found that RBD Nbs are highly resistant to variants of concern (VOCs). High-resolution cryoelectron microscopy determination of eight Nb-bound structures reveals multiple potent neu...
1 CitationsSource
#1Sun D (HUJI: Hebrew University of Jerusalem)H-Index: 1
#1Dapeng Sun (University of Pittsburgh)H-Index: 2
Last. Yi ShiH-Index: 21
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There is an urgent need to develop effective interventions resistant to the evolving variants of SARS-CoV-2. Nanobodies (Nbs) are stable and cost-effective agents that can be delivered by novel aerosolization route to treat SARS-CoV-2 infections efficiently. However, it remains unknown if they possess broadly neutralizing activities against the prevalent circulating strains. We found that potent neutralizing Nbs are highly resistant to the convergent variants of concern that evade a large panel ...
8 CitationsSource
#1Michael J. TiszaH-Index: 7
#2Anna K. BelfordH-Index: 4
Last. Christopher B. BuckH-Index: 52
view all 5 authors...
Viruses, despite their great abundance and significance in biological systems, remain largely mysterious. Indeed, the vast majority of the perhaps hundreds of millions of viral species on the planet remain undiscovered. Additionally, many viruses deposited in central databases like GenBank and RefSeq are littered with genes annotated as 'hypothetical protein' or the equivalent. Cenote-Taker 2, a virus discovery and annotation tool available on command line and with a graphical user interface wit...
2 CitationsSource
#1Gabriel J. StarrettH-Index: 21
#2Michael J. TiszaH-Index: 7
Last. Christopher B. BuckH-Index: 52
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4 CitationsSource
#1Michael J. TiszaH-Index: 7
#2Anna K. BelfordH-Index: 4
Last. Christopher B. BuckH-Index: 52
view all 6 authors...
Viruses, despite their great abundance and significance in biological systems, remain largely mysterious. Indeed, the vast majority of the perhaps hundreds of millions of viral species on the planet remain undiscovered. Additionally, many viruses deposited in central databases like GenBank and RefSeq are littered with genes annotated as hypothetical protein or the equivalent. Cenote-Taker2, a virus discovery and annotation tool available on command line and with a graphical user interface with f...
1 CitationsSource
#1Nicole L. WelchH-Index: 5
#2Michael J. TiszaH-Index: 7
Last. Christopher B. BuckH-Index: 52
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Abstract Adenoviruses, papillomaviruses, and polyomaviruses are collectively known as small DNA tumor viruses. Although it has long been recognized that small DNA tumor virus oncoproteins and capsid proteins show a variety of structural and functional similarities, it is unclear whether these similarities reflect descent from a common ancestor, convergent evolution, horizontal gene transfer among virus lineages, or acquisition of genes from host cells. Here, we report the discovery of a dozen ne...
6 CitationsSource
#1Gabriel J. StarrettH-Index: 21
#2Michael J. TiszaH-Index: 7
Last. Christopher B. BuckH-Index: 52
view all 7 authors...
Abstract Polintons (also known as Mavericks) were initially identified as a widespread class of eukaryotic transposons named for their hallmark type B DNA polymerase and retrovirus-like integrase genes. It has since been recognized that many polintons encode possible capsid proteins and viral genome-packaging ATPases similar to those of a diverse range of double-stranded DNA (dsDNA) viruses. This supports the inference that at least some polintons are viruses that remain capable of cell-to-cell ...
4 CitationsSource
#1Nicole L. WelchH-Index: 5
#2Michael J. TiszaH-Index: 7
Last. Christopher B. BuckH-Index: 52
view all 18 authors...
Adenoviruses, papillomaviruses, parvoviruses and polyomaviruses are collectively known as small DNA tumor viruses. Although it has long been recognized that small DNA tumor virus oncoproteins and capsid proteins show a variety of structural and functional similarities, it is unclear whether these similarities reflect descent from a common ancestor, convergent evolution, horizontal gene transfer among virus lineages, or repeated acquisition of genes from host cells. We report the discovery of fou...
3 CitationsSource