Shereen Kesserwan
Wayne State University
ChemistryMaterials scienceIn vitroIn vivoFibrilInflammationSalineMacrophageInsulinGlycemicFibrosisInfusion SiteIn vitro cytotoxicityInsulin dependent diabetesExogenous insulinDiabetes mellitusPreservativeCell culturePharmacology
2Publications
2H-index
0Citations
Publications 4
Newest
#1Shereen Kesserwan (WSU: Wayne State University)H-Index: 2
#2Li Mao (WSU: Wayne State University)H-Index: 1
Last. Ulrike Klueh (WSU: Wayne State University)H-Index: 16
view all 5 authors...
Background Extending the lifespan of subcutaneous insulin administration sets and infusion pumps requires overcoming unreliable insulin delivery induced by dermal reactions. All commercially available insulin formulations contain insulin phenolic preservatives (IPP), which stabilize the insulin molecule but result in unwanted cell and tissue toxicity. Mast cells, which are the first line of defense once the epithelium is breached, are particularly abundant beneath the skin surface. Thus, we hypo...
Source
#1Brianne E. Lewis (WSU: Wayne State University)H-Index: 6
#2Adam Mulka (WSU: Wayne State University)H-Index: 2
Last. Ulrike Klueh (WSU: Wayne State University)H-Index: 16
view all 9 authors...
Background:Effective exogenous insulin delivery is the cornerstone of insulin dependent diabetes mellitus management. Recent literature indicates that commercial insulin-induced tissue reaction and...
Source
#1Shereen Kesserwan (WSU: Wayne State University)H-Index: 2
#2Adam Mulka (WSU: Wayne State University)H-Index: 2
Last. Ulrike Klueh (WSU: Wayne State University)H-Index: 16
view all 7 authors...
Continuous Subcutaneous Insulin Infusion (CSII) is superior to conventional insulin therapy as it improves glycemic control thus reducing the probability of diabetic complications. Notwithstanding CSII's benefits, insulin dependent diabetic patients rarely achieve optimal glucose control. Moreover, CSII is only FDA approved for 3 days and often fails prematurely for reasons that have not been fully elucidated. We hypothesize that phenolic compounds, such as m-cresol and phenol, which are present...
Source
#1Adam MulkaH-Index: 2
#3Li MaoH-Index: 1
Last. Ulrike KluehH-Index: 16
view all 8 authors...
Background: Exogenous insulin therapy requires stabilization of the insulin molecule, which is achieved through the use of excipients (e.g., phenolic preservatives (PP)) that provide protein stabil...
Source
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