Ishwar N. Kohale
Massachusetts Institute of Technology
Environmental chemistryCytotoxicityCancerInternal medicineDNA damageOncologyClinical study designEfficacyKinaseChemistryBase excision repairDNA glycosylaseLethalityLung cancerNitrosamineBenzo(a)pyreneTyrosine phosphorylationPyrenePolycyclic aromatic hydrocarbonTriple-negative breast cancerTargeted therapyMolecular ResponseDNA Strand BreakDNA Repair ProteinHuman healthFormalin fixed paraffin embeddedPatient specificCancer riskTumor tissuePhases of clinical researchMutationCancer researchBreast cancerClinical trialDrug developmentPhosphoproteomicsMedicineTandem mass tagBiologyQuantitative analysis (chemistry)
6Publications
1H-index
2Citations
Publications 5
Newest
#1Jamie M. KellyH-Index: 2
#2Peter D. IvattH-Index: 5
Last. Noelle E. SelinH-Index: 44
view all 9 authors...
Scientists and regulators commonly use benzo[a]pyrene concentrations to assess cancer risk from complex mixtures of atmospheric polycyclic aromatic hydrocarbons (PAHs). Here, we show that benzo[a]p...
Source
#1Begoña Giménez-Cassina López (Brigham and Women's Hospital)H-Index: 13
#2Ishwar N. Kohale (MIT: Massachusetts Institute of Technology)H-Index: 1
Last. Michael S. Regan (Brigham and Women's Hospital)H-Index: 7
view all 28 authors...
Background null Response to targeted therapy varies between patients for largely unknown reasons. Here, we developed and applied an integrative platform using mass spectrometry imaging (MSI), phosphoproteomics, and multiplexed tissue imaging for mapping drug distribution, target engagement, and adaptive response to gain insights into heterogeneous response to therapy. null Methods null Patient derived xenograft (PDX) lines of glioblastoma were treated with adavosertib, a Wee-1 inhibitor, and tis...
Source
#1Ishwar N. Kohale (MIT: Massachusetts Institute of Technology)H-Index: 1
#2Danielle M. Burgenske (Mayo Clinic)H-Index: 2
Last. Forest M. White (MIT: Massachusetts Institute of Technology)H-Index: 60
view all 12 authors...
Human tissue samples commonly preserved as formalin-fixed paraffin-embedded (FFPE) tissues after diagnostic or surgical procedures in the clinic represent an invaluable source of clinical specimens for in-depth characterization of signaling networks to assess therapeutic options. Tyrosine phosphorylation (pTyr) plays a fundamental role in cellular processes and is commonly dysregulated in cancer but has not been studied to date in FFPE samples. Additionally, pTyr analysis that may otherwise info...
Source
#1Jennifer E. Kay (MIT: Massachusetts Institute of Technology)H-Index: 49
#2Joshua J. Corrigan (MIT: Massachusetts Institute of Technology)H-Index: 8
Last. Bevin P. Engelward (MIT: Massachusetts Institute of Technology)H-Index: 32
view all 15 authors...
Summary N-Nitrosodimethylamine (NDMA) is a DNA-methylating agent that has been discovered to contaminate water, food, and drugs. The alkyladenine DNA glycosylase (AAG) removes methylated bases to initiate the base excision repair (BER) pathway. To understand how gene-environment interactions impact disease susceptibility, we study Aag-knockout (Aag−/−) and Aag-overexpressing mice that harbor increased levels of either replication-blocking lesions (3-methyladenine [3MeA]) or strand breaks (BER in...
Source
#1Jamie M. Kelly (MIT: Massachusetts Institute of Technology)H-Index: 2
#2Noelle E. Selin (MIT: Massachusetts Institute of Technology)H-Index: 44
Last. Amy Hrdina (MIT: Massachusetts Institute of Technology)H-Index: 2
view all 8 authors...
Close Researchers
Forest M. White
H-index : 60
Massachusetts Institute of Technology
Bevin P. Engelward
H-index : 32
Massachusetts Institute of Technology
Jann N. Sarkaria
H-index : 70
Mayo Clinic
Jesse H. Kroll
H-index : 62
Massachusetts Institute of Technology
John M. Essigmann
H-index : 69
Massachusetts Institute of Technology
Dorothea K. Torous
H-index : 26
University of Rochester
Ilana S Nazari
H-index : 1
Massachusetts Institute of Technology
Jenevieve Kuang
H-index : 2
Massachusetts Institute of Technology
R G Croy
H-index : 17
Harvard University
Amanda Lee Armijo
H-index : 2
Massachusetts Institute of Technology
Svetlana L. Avlasevich
H-index : 19
University of Rochester
Amy Hrdina
H-index : 2
Massachusetts Institute of Technology
Liewei Wang
H-index : 1
Mayo Clinic
Peter D. Ivatt
H-index : 5
University of York
Jamie M. Kelly
H-index : 2
Massachusetts Institute of Technology
Danielle M. Burgenske
H-index : 2
Mayo Clinic
Sebastian E. Carrasco
H-index : 8
Massachusetts Institute of Technology
Eric B. Haura
H-index : 70
University of South Florida
Noelle E. Selin
H-index : 44
Massachusetts Institute of Technology
Matthew P. Goetz
H-index : 60
Mayo Clinic
Jodi M. Carter
H-index : 23
Mayo Clinic
Joshua J. Corrigan
H-index : 8
Massachusetts Institute of Technology
Ann C. Mladek
H-index : 21
Mayo Clinic
Jennifer E. Kay
H-index : 49
Cooperative Institute for Research in Environmental Sciences
Stephen D. Dertinger
H-index : 51
University of Rochester
Leona D. Samson
H-index : 75
Massachusetts Institute of Technology
Katrina K. Bakken
H-index : 8
Mayo Clinic
Robert G. Croy
H-index : 12
Massachusetts Institute of Technology
Dushan N. Wadduwage
H-index : 6
Massachusetts Institute of Technology
Judy C. Boughey
H-index : 61
Mayo Clinic
Mathew J. Evans
H-index : 54
University of York
Judy C. Boughey
H-index : 18
University of Texas MD Anderson Cancer Center
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