Saki Kuwahara
Chiba University
Genetically modified mouseHuman leukocyte antigenImmunologyAnimal modelDrug toxicityBiology
1Publications
0Citations
Publications 3
Newest
#1Binbin Song (MOE: Chinese Ministry of Education)H-Index: 3
#2Shigeki Aoki (Chiba University)H-Index: 7
Last. Kousei Ito (Chiba University)H-Index: 29
view all 6 authors...
Abstract null null Based on recent genome-wide association studies, abacavir-induced hypersensitivity is highly associated with human leukocyte antigen (HLA)-B*57:01 allele. However, the underlying mechanism of this occurrence is unclear. To investigate the underlying mechanism, we developed HLA-B*57:01 transgenic mice and found that application of abacavir could cause CD8 T cell activation with elevation in PD1 expression; however, severe skin hypersensitivity was not observed. To eliminate the...
Source
#1Takeshi Susukida (University of Toyama)H-Index: 5
#2Saki Kuwahara (Chiba University)
Last. Kousei Ito (Chiba University)H-Index: 29
view all 6 authors...
Idiosyncratic drug toxicity (IDT) associated with specific human leukocyte antigen (HLA) allotype is a rare and unpredictable life-threatening adverse drug reaction for which prospective mechanistic studies in humans are difficult. Here, we show the importance of immune tolerance for IDT onset and determine whether it is susceptible to a common IDT, HLA-B*57:01-mediated abacavir (ABC)-induced hypersensitivity (AHS), using CD4+ T cell-depleted programmed death-1 receptor (PD-1)-deficient HLA-B*57...
Source
#1Takeshi Susukida (University of Toyama)H-Index: 5
#2Shigeki Aoki (Chiba University)H-Index: 7
Last. Kousei Ito (Chiba University)H-Index: 29
view all 6 authors...
Various types of transgenic mice carrying either class I or II human leukocyte antigen (HLA) molecules are readily available, and reports describing their use in a variety of studies have been publ...
2 CitationsSource