Toni Todorovski
Pompeu Fabra University
Binding siteCytotoxicityBiological activityAmine gas treatingKinetic energyKineticsSomatostatin receptor 2Peptide sequenceLigationChemistryChemoselectivityStructure–activity relationshipIn vitroImmunologyEpimerProtein foldingWW domainIn vivoCombinatorial chemistryColitisSomatostatinInflammationInflammatory Bowel DiseasesCortistatinInflammatory bowel diseaseBlood–brain barrierThioesterDiseaseCysteinePeptideAntiviral drugAlanineUlcerative colitisGastrointestinal tractModern medicineStructure basedAmino acidRational designExperimental dataBiochemistryMolecular dynamicsBioinformaticsStereochemistryMedicineDrug discoveryCrystallographyImmune systemForce field (chemistry)ThermodynamicsPharmacologyChemical ligationScaling
Publications 6
#1Diogo A. Mendonça (IMM: Instituto de Medicina Molecular)H-Index: 2
#2Mariët Bakker (Avans University of Applied Sciences)
Last. Toni Todorovski (UPF: Pompeu Fabra University)H-Index: 7
view all 12 authors...
Passing through the blood-brain barrier (BBB) to treat neurological conditions is one of the main hurdles in modern medicine. Many drugs with promising in vitro profiles become ineffective in vivo due to BBB restrictive permeability. In particular, this includes drugs such as antiviral porphyrins, with the ability to fight brain-resident viruses causing diseases such as HIV-associated neurocognitive disorders (HAND). In the last two decades, BBB shuttles, particularly peptide-based ones, have sh...
#1Alvaro RolH-Index: 1
#2Toni Todorovski (UPF: Pompeu Fabra University)H-Index: 7
Last. Maria J. Macias (Catalan Institution for Research and Advanced Studies)H-Index: 27
view all 15 authors...
Ulcerative colitis and Crohn’s disease are forms of inflammatory bowel disease whose incidence and prevalence are increasing worldwide. These diseases lead to chronic inflammation of the gastrointestinal tract as a result of an abnormal response of the immune system. Recent studies positioned Cortistatin, which shows low stability in plasma, as a candidate for IBD treatment. Here, using NMR structural information, we design five Cortistatin analogues adopting selected native Cortistatin conforma...
1 CitationsSource
#1Alvaro RolH-Index: 1
#2Toni TodorovskiH-Index: 7
Last. Maria J. MaciasH-Index: 27
view all 15 authors...
Ulcerative colitis and Crohn9s disease are inflammatory bowel diseases (IBD) that lead to chronic inflammations of the gastrointestinal tract due to an abnormal response of the immune system. Finding new effective drugs to tackle IBD represents a major therapeutic concern since IBD incidence and prevalence is increasing worldwide. Recent studies positioned Cortistatin (CST) as a candidate for IBD treatment due to its anti-inflammatory and immunomodulatory activity. Here, we studied the structura...
#1Pablo Martín-GagoH-Index: 11
#2Alvaro RolH-Index: 1
Last. Antoni RieraH-Index: 56
view all 11 authors...
Peptide aromatic interactions modulated by fluorinated residues: Synthesis, structure and biological activity of Somatostatin analogs containing 3-(3′,5′difluorophenyl)-alanine
5 CitationsSource
#1Toni TodorovskiH-Index: 7
#2David SuñolH-Index: 3
Last. Maria J. Macias (Catalan Institution for Research and Advanced Studies)H-Index: 27
view all 4 authors...
The syntheses of large peptides and of those containing non-natural amino acids can be facilitated by the application of convergent approaches, dissecting the native sequence into segments connected through a ligation reaction. We describe an improvement of the ligation protocol used to prepare peptides and proteins without cysteine residues at the ligation junction. We have found that the addition of HOBt to the ligation, improves the conversion of the ligation reaction without affecting the ep...
1 CitationsSource
#1Rui Zhou (University of Gdańsk)H-Index: 3
#2Gia G. Maisuradze (Cornell University)H-Index: 15
Last. Adam Liwo (University of Gdańsk)H-Index: 55
view all 9 authors...
In spite of recent advances made in computer simulation techniques, one of the main challenges in the protein-folding field is to bridge microscopic motions and experimental measurements. This paper demonstrates that the physics-based, coarse-grained united-residue (UNRES) force field, which has the ability to simulate folding of small- and midsize proteins in the millisecond timescale, can predict the folding kinetics correctly and bridge theoretical and experimental worlds. The results suggest...
24 CitationsSource