Adrian L. Harris
University of Oxford
CancerInternal medicineEndocrinologyPathologyOncologyGene expressionMolecular biologyChemistryImmunohistochemistryVascular endothelial growth factorNeovascularizationMetastasisHypoxia (medical)AngiogenesisCancer researchBreast cancerMedicineBiologyCell biologyCancer cellPharmacology
Publications 1214
#1Helen Sheldon (University of Oxford)H-Index: 18
#2Esther Bridges (University of Oxford)H-Index: 10
Last. Mira Kreuzer (University of Oxford)
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ELTD1/ADGRL4 expression is increased in the vasculature of a number of tumour types and this correlates with a good prognosis. Expression has also been reported in some tumour cells with high expression correlating with a good prognosis in hepatocellular carcinoma and a poor prognosis in glioblastoma. Here we show that 35% of primary human breast tumours stain positively for ELTD1, with 9% having high expression that correlates with improved relapse free survival. Using immunocompetent, syngenei...
#1Alexandra Giatromanolaki (DUTH: Democritus University of Thrace)H-Index: 76
#2Adrian L. Harris (University of Oxford)H-Index: 191
Last. Michael I. Koukourakis (DUTH: Democritus University of Thrace)H-Index: 74
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BACKGROUND Arginine (Arg) is essential for cancer cell growth and also for the activation of T cells. Thus, therapies aiming to reduce Arg utilization by cancer may prove detrimental for the immune response. METHODS We examined the expression of two major enzymes involved in arginine depletion and replenishment, namely arginase ARG2 and argininosuccinate synthase ASS1, respectively, in a series of 98 NSCLCs. Their association with immune infiltrates and the postoperative outcome were also studie...
#1Ahmed M. AlaaH-Index: 17
#2Deepti GurdasaniH-Index: 19
Last. Mihaela van der SchaarH-Index: 43
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#1Rebecca Westbrook (University of Birmingham)H-Index: 1
#2Esther Bridges (University of Oxford)H-Index: 10
Last. Kattri-Liis Eskla (UT: University of Tartu)H-Index: 6
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The demands of cancer cell proliferation alongside an inadequate angiogenic response leads to insufficient oxygen availability in the tumour microenvironment. Within the mitochondria, oxygen is the major electron acceptor for NADH, with the result that the reducing activity of the tricarboxylic acid (TCA) cycle and mitochondrial respiration are functionally linked. As the oxidising activity of the TCA cycle is required for efficient synthesis of anabolic precursors, tumoral hypoxia could lead to...
#1Viola Fanfani (Edin.: University of Edinburgh)H-Index: 1
#2Martina Zatopkova (University of Ostrava)H-Index: 2
Last. Giovanni Stracquadanio (Edin.: University of Edinburgh)H-Index: 2
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Decades of research have shown that rare highly penetrant mutations can promote tumorigenesis, but it is still unclear whether variants observed at high-frequency in the broader population could modulate the risk of developing cancer. Genome-wide Association Studies (GWAS) have generated a wealth of data linking single nucleotide polymorphisms (SNPs) to increased cancer risk, but the effect of these mutations are usually subtle, leaving most of cancer heritability unexplained. Understanding the ...
3 CitationsSource
#1Hanna Sjoberg (University of Oxford)H-Index: 7
#2Yiannis Philippou (University of Oxford)H-Index: 9
Last. Jens Rittscher (University of Oxford)H-Index: 27
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There is a need to improve the treatment of prostate cancer (PCa) and reduce treatment side effects. Vascular-targeted photodynamic therapy (VTP) is a focal therapy for low-risk low-volume localised PCa, which rapidly disrupts targeted tumour vessels. There is interest in expanding the use of VTP to higher-risk disease. Tumour vasculature is characterised by vessel immaturity, increased permeability, aberrant branching and inefficient flow. FRT alters the tumour microenvironment and promotes tra...
#1Matteo Di Giovannantonio (University of Oxford)H-Index: 1
#2Benjamin Howell Lole Harris (University of Oxford)H-Index: 4
Last. Gareth L. BondH-Index: 25
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BACKGROUND Height and other anthropometric measures are consistently found to associate with differential cancer risk. However, both genetic and mechanistic insights into these epidemiological associations are notably lacking. Conversely, inherited genetic variants in tumour suppressors and oncogenes increase cancer risk, but little is known about their influence on anthropometric traits. METHODS By integrating inherited and somatic cancer genetic data from the Genome-Wide Association Study Cata...
#1Ruben S.A. Goedegebuure (VUMC: Vanderbilt University Medical Center)H-Index: 2
#2Esther A Kleibeuker (VUMC: Vanderbilt University Medical Center)
Last. Victor L. J. L. Thijssen (VUMC: Vanderbilt University Medical Center)H-Index: 2
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BACKGROUND Improvement of radiotherapy efficacy requires better insight in the dynamic responses that occur during irradiation. Here, we aimed to identify the molecular responses that are triggered during clinically applied fractionated irradiation. METHODS Gene expression analysis was performed by RNAseq or microarray analysis of cancer cells or xenograft tumors, respectively, subjected to 3-5 weeks of 5 × 2 Gy/week. Validation of altered gene expression was performed by qPCR and/or ELISA in mu...
#1David M Favara (University of Oxford)H-Index: 4
#2Ines Liebscher (Leipzig University)H-Index: 16
Last. Adrian L. Harris (University of Oxford)H-Index: 191
view all 7 authors...
ADGRL4/ELTD1 is an orphan adhesion GPCR (aGPCR) expressed in endothelial cells that regulates tumour angiogenesis. The majority of aGPCRs are orphan receptors. The Stachel Hypothesis proposes a mechanism for aGPCR activation, in which aGPCRs contain a tethered agonist (termed Stachel) C-terminal to the GPCR-proteolytic site (GPS) cleavage point which, when exposed, initiates canonical GPCR signalling. This has been shown in a growing number of aGPCRs. We tested this hypothesis on ADGRL4/ELTD1 by...