Mangze Hu
Nantong University
Mitogen-activated protein kinaseChemistryHsp90Lung cancerKRASProgrammed cell deathReactive oxygen speciesCancer researchCell growthPI3K/AKT/mTOR pathway
Publications 1
#1Mangze Hu (Nantong University)H-Index: 1
#2Yu Zhao (Nantong University)H-Index: 11
Last. Xiaorong Zhou (Nantong University)H-Index: 1
view all 7 authors...
Metabolic alterations are well documented in various cancers. Non-small cell lung cancers (NSCLCs) preferentially use lactate as the primary carbon source, but the underlying mechanisms are not well understood. We developed a lactate-dependent cell proliferation assay and found that dynamin-related protein (DRP1), which is highly expressed in KRAS-mutant NSCLC, is required for tumor cells to proliferate and uses lactate as fuel, demonstrating the critical role of DRP1 in the metabolic reprogramm...
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.