Yuejiao Cao
Nantong University
Mitogen-activated protein kinaseGene knockdownChemistryTranscriptional regulationHsp90Tumor microenvironmentLung cancerImmunotherapyKRASProgrammed cell deathEpigeneticsReactive oxygen speciesMutationCancer researchCell growthPI3K/AKT/mTOR pathwayBiologyImmune system
Publications 2
#1Yu Zhao (Nantong University)H-Index: 10
#2Yuejiao Cao (Nantong University)H-Index: 1
Last. Xiaorong Zhou (Nantong University)H-Index: 4
view all 7 authors...
Loss of the B2M gene is associated with tumor immune escape and resistance to immunotherapy. However, genetic alterations of the B2M gene are rare. We performed an integrative analysis of the mutational and transcriptional profiles of large cohorts of non-small-cell lung cancer (NSCLC) patients and found that epigenetic downregulation of B2M is common. B2M-low tumors exhibit a suppressive immune microenvironment characterized by reduced infiltration of immune cells of various lineages; in B2M-hi...
#1Mangze Hu (Nantong University)H-Index: 1
#2Yu Zhao (Nantong University)H-Index: 10
Last. Xiaorong Zhou (Nantong University)H-Index: 1
view all 7 authors...
Metabolic alterations are well documented in various cancers. Non-small cell lung cancers (NSCLCs) preferentially use lactate as the primary carbon source, but the underlying mechanisms are not well understood. We developed a lactate-dependent cell proliferation assay and found that dynamin-related protein (DRP1), which is highly expressed in KRAS-mutant NSCLC, is required for tumor cells to proliferate and uses lactate as fuel, demonstrating the critical role of DRP1 in the metabolic reprogramm...
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