Jun Ni
Fujian Medical University
Mitogen-activated protein kinaseChemistryHsp90Lung cancerKRASProgrammed cell deathReactive oxygen speciesCancer researchCell growthPI3K/AKT/mTOR pathway
2Publications
1H-index
2Citations
Publications 1
Newest
#1Mangze Hu (Nantong University)H-Index: 1
#2Yu Zhao (Nantong University)H-Index: 11
Last. Xiaorong Zhou (Nantong University)H-Index: 1
view all 7 authors...
Metabolic alterations are well documented in various cancers. Non-small cell lung cancers (NSCLCs) preferentially use lactate as the primary carbon source, but the underlying mechanisms are not well understood. We developed a lactate-dependent cell proliferation assay and found that dynamin-related protein (DRP1), which is highly expressed in KRAS-mutant NSCLC, is required for tumor cells to proliferate and uses lactate as fuel, demonstrating the critical role of DRP1 in the metabolic reprogramm...
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