Genevieve A. Perono
McMaster University
EcosystemOffspringLivestockAgricultureMetabolomeFunction (biology)Vascular endothelial growth factor AFood chainTranscriptomeAnimal studiesFetusChemistryTranscriptional regulationSerotoninCannabisTrophoblastAromatic hydrocarbonSmoking cessationDibenzothiophenePregnancyNeurotoxicityNicotineGap analysis (conservation)Effects of cannabisAngiogenesisMicroplasticsNicotine replacement therapyCannabinoidTryptophan MetabolismTrophoblast cellPlacental dysfunctionBiotaToxicityPlant growthRare earthIntensive careMolecular evidencePlant systemReceptor expressionCannabis useTube formationEnvironmental scienceSignallingPhysiologyEndocannabinoid systemPeripheralPharmacotherapyEnvironmental protectionBiochemistryBioinformaticsComputational biologyMedicineANGPTL4Cell biologyEnvironmental health
7Publications
2H-index
4Citations
Publications 8
Newest
#1Sergio Raez-Villanueva (McMaster University)H-Index: 2
#2Genevieve A. Perono (McMaster University)H-Index: 2
Last. Alison C. Holloway (McMaster University)H-Index: 47
view all 5 authors...
Worldwide demand for petroleum products has resulted in increased oil and gas activities in many countries. Conventional and unconventional oil and gas extraction, production, and transport lead to increased levels of petroleum-derived polycyclic aromatic hydrocarbons (PAHs) in the environment. PAH exposure has profound effects on reproduction by affecting pathways involved in placental trophoblast cell function and impairing normal placental development and function-key contributors to reproduc...
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#1Annia A Martínez-Peña (McMaster University)
#2Genevieve A. Perono (McMaster University)H-Index: 2
Last. Sandeep Raha (McMaster University)H-Index: 29
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Cannabis use during pregnancy has continued to rise, particularly in developed countries, as a result of the trend towards legalization and lack of consistent, evidence-based knowledge on the matter. While there is conflicting data regarding whether cannabis use during pregnancy leads to adverse outcomes such as stillbirth, preterm birth, low birthweight, or increased admission to neonatal intensive care units, investigations into long-term effects on the offspring’s health are limited. Historic...
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#1Philippe J. Thomas (Carleton University)H-Index: 13
#2Genevieve A. Perono (McMaster University)H-Index: 2
Last. Daniel Mark LyonsH-Index: 18
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Abstract The pervasive spread of microplastics (MPs) and nanoplastics (NPs) has raised significant concerns on their toxicity in both aquatic and terrestrial environments. These polymer-based materials have implications for plants, wildlife and human health, threatening food chain integrity and ultimate ecosystem resilience. An extensive – and growing – body of literature is available on MP- and NP-associated effects, including in a number of aquatic biota, with as yet limited reports in terrest...
3 CitationsSource
#1Laiba Jamshed (McMaster University)H-Index: 2
#2Genevieve A. Perono (McMaster University)H-Index: 2
Last. Alison C. Holloway (McMaster University)H-Index: 47
view all 6 authors...
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#1Franca TommasiH-Index: 19
#2Philippe J. Thomas (Carleton University)H-Index: 13
Last. Marco Trifuoggi (University of Naples Federico II)H-Index: 20
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Rare earth elements (REEs) are key constituents of modern technology and play important roles in various chemical and industrial applications. They also are increasingly used in agricultural and zootechnical applications, such as fertilizers and feed additives. Early applications of REEs in agriculture have originated in China over the past several decades with the objective of increasing crop productivity and improving livestock yield (e.g., egg production or piglet growth). Outside China, REE ...
6 CitationsSource
#1Laiba JamshedH-Index: 2
Last. Alison C. Holloway (McMaster University)H-Index: 47
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Cigarette smoking during pregnancy is associated with numerous obstetrical, fetal and developmental complications, as well as an increased risk of adverse health consequences in the adult offspring. Nicotine replacement therapy (NRT) and electronic nicotine delivery systems (e-cigarettes) have been developed as a pharmacotherapy for smoking cessation and are considered safer alternatives for women to smoke during pregnancy. The safety of NRT use during pregnancy has been evaluated in a limited n...
5 CitationsSource
For years, cannabis has been largely used for its mind-altering properties. However, the discovery of its medicinal and therapeutic attributes has led to increased medicinal use. With recent legali...
1 CitationsSource
#1Laiba Jamshed (McMaster University)H-Index: 2
#2Sergio Raez-Villanueva (McMaster University)H-Index: 2
Last. Alison C. Holloway (McMaster University)H-Index: 47
view all 5 authors...
Abstract There is considerable concern that naphthenic acids (NA) related to oil extraction can negatively impact reproduction in mammals, yet the mechanisms are unknown. Since placental dysfunction is central to many adverse pregnancy outcomes, the goal of this study was to determine the effects of NA exposure on placental trophoblast cell function. HTR-8/SVneo cells were exposed to a commercial technical NA mixture for 24 hours to assess transcriptional regulation of placentation-related pathw...
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