Xiaodan Xu
Zhejiang University
Biomedical engineeringMagnetic resonance imagingNanoparticlePhotothermal therapyChemistryMaterials scienceIn vivoBiocompatibilityHyaluronic acidIron oxide nanoparticlesMetastasisLiver tissueT1 contrastHighly sensitiveTumor inhibitionPolymerizationCancer researchGlutathioneMagnetic nanoparticlesCancer cell
Publications 3
#1Xiaoxuan Zhou (SRRSH: Sir Run Run Shaw Hospital)H-Index: 4
#2Chengbin He (SRRSH: Sir Run Run Shaw Hospital)
Last. Hongjie Hu (SRRSH: Sir Run Run Shaw Hospital)H-Index: 9
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Theranostic nanoparticles (NPs) have emerged as promising candidates for cancer diagnosis and treatment. Manganese dioxide (MnO2)-based NPs are potential contrast agents with excellent paramagnetic property and biocompatibility, exhibiting satisfactory magnetic resonance imaging (MRI) effects and biological safety. Recently, hyaluronic acid (HA) has gained increasing interest due to its tumor-targeting ability, which can improve the tumor affinity of manganese dioxide (MnO2)-based NPs. In this s...
1 CitationsSource
#1Xiaodan Xu (ZJU: Zhejiang University)
#2Xiaoxuan Zhou (SRRSH: Sir Run Run Shaw Hospital)H-Index: 4
Last. Jianbin Tang (ZJU: Zhejiang University)H-Index: 31
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Liver metastasis (LM) occurs in various cancers, and its early and accurate diagnosis is of great importance. However, the detection of small LMs is still a great challenge because of the subtle differences between normal liver tissue and small metastases. Herein, we prepare glutathione (GSH)-responsive hyaluronic acid-coated iron oxide nanoparticles (HIONPs) for highly sensitive diagnosis of LMs through a facile one-pot method. HIONPs greatly enhance the signal of MRI in tumor metastases as T1 ...
#1Bing Xiao (ZJU: Zhejiang University)H-Index: 3
#2Xiaoxuan Zhou (SRRSH: Sir Run Run Shaw Hospital)H-Index: 4
Last. Youqing Shen (ZJU: Zhejiang University)H-Index: 63
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Nanotechnology has a remarkable impact on the preclinical development of future medicines. However, the complicated preparation and systemic toxicity to living systems prevent them from translation to clinical applications. In the present report, we developed a polyepicatechin-based on/off switchable ultra-sensitive magnetic resonance imaging (MRI) visible theranostic nanoparticle (PEMN) for image-guided photothermal therapy (PTT) using our strategy of integrating polymerization and biomineraliz...