Jingru Shi
Yangzhou University
Drug resistanceMultiple drug resistanceMultidrug toleranceChemistryIn vivoGram-negative bacteriaMelatoninCiprofloxacinColistinBenzydamineIodonitrotetrazoliumAntibioticsRepurposingBacteriaAntimicrobial peptidesMedicineBiologyMicrobiologyAntibiotic resistancePharmacology
9Publications
2H-index
6Citations
Publications 10
Newest
#1Yuan Liu (YZU: Yangzhou University)H-Index: 9
#2Kangni Yang (YZU: Yangzhou University)H-Index: 3
Last. Zhiqiang Wang (YZU: Yangzhou University)H-Index: 8
view all 11 authors...
Antibiotic tolerance, the ability of a typically susceptible microorganism to survive extended periods of exposure to antibiotics, has a critical role in chronic and recurrent bacterial infections, and facilitates the evolution of antibiotic resistance. However, the physiological factors that contribute to the development of antibiotic tolerance, particularly in vivo, are not fully known. Despite the fact that a high-fat diet (HFD) is implicated in several human diseases, the relationship betwee...
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#1Yuan Liu (YZU: Yangzhou University)H-Index: 9
#1Yang Liu (YZU: Yangzhou University)H-Index: 60
Last. Zhiqiang Wang (YZU: Yangzhou University)H-Index: 8
view all 7 authors...
Antimicrobial resistance has been a growing concern that gradually undermines our tradition treatment regimen. The fact that few antibacterial drugs with new scaffolds or targets have been approved in the past two decades aggravates this crisis. Repurposing previously approved drugs as potent antibiotic adjuvants offers a cost effective strategy to mitigate the development of resistance and tackle the increasing infections by multidrug resistant (MDR) bacteria. Herein, we found that benzydamine,...
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#1Jingru ShiH-Index: 2
Last. Liu Yuan
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The emergence and prevalence of multidrug-resistant (MDR) bacteria have posed a serious threat to public health. Of particular concern are methicillin-resistant Staphylococcus aureus (MRSA) and blaNDM, mcr-1 and tet(X)-positive Gram-negative pathogens. The fact that few new antibiotics have been approved in recent years exacerbates this global crisis, thus, new alternatives are urgently needed. Antimicrobial peptides (AMPs) originated from host defense peptides with a wide range of sources and m...
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#1Yuan Liu (YZU: Yangzhou University)H-Index: 9
#2Ziwen Tong (YZU: Yangzhou University)H-Index: 2
Last. Zhiqiang Wang (YZU: Yangzhou University)H-Index: 8
view all 6 authors...
Antimicrobial resistance has been a global health challenge that threatens our ability to control and treat life-threatening bacterial infections. Despite ongoing efforts to identify new drugs or alternatives to antibiotics, no new classes of antibiotic or their alternatives have been clinically approved in the last three decades. A combination of antibiotics and non-antibiotic compounds that could inhibit bacterial resistance determinants or enhance antibiotic activity offers a sustainable and ...
2 CitationsSource
#1Yuan Liu (YZU: Yangzhou University)H-Index: 9
#1Liu Yuan (Ministry of Education)
Last. Wang Zhiqiang (Ministry of Education)
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The antibiotic resistance crisis is becoming incredibly thorny due to the indiscriminate employment of antibiotics in agriculture and aquaculture, such as growth promoters, and the emergence of bacteria that are capable of enduring antibiotic treatment in an endless stream. Hence, to reverse this situation, vigorous efforts should be made in the process of identifying other alternative strategies with a lower frequency of resistance. Antimicrobial peptides (AMPs), originated from host defense pe...
2 CitationsSource
#1Yuan LiuH-Index: 9
#2Kangni YangH-Index: 3
Last. Zhiqiang WangH-Index: 8
view all 6 authors...
Diminished antibiotic susceptibility of bacterial pathogens is an increasingly serious threat to human and animal health. Alternative strategies are required to combat antibiotic refractory bacteria. Bacterial metabolic state has been shown to play a critical role in its susceptibility to antibiotic killing. However, the adjuvant potential of nucleotides in combination with antibiotics to kill Gram-negative pathogens remains unknown. Herein, we found that thymine potentiates ciprofloxacin killin...
1 CitationsSource
#1Yuan Liu (YZU: Yangzhou University)H-Index: 9
#2Jingru Shi (YZU: Yangzhou University)H-Index: 2
Last. Zhiqiang Wang (YZU: Yangzhou University)H-Index: 8
view all 6 authors...
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#1Yuan LiuH-Index: 9
#2Yuqian JiaH-Index: 3
Last. Zhiqiang Wang (YZU: Yangzhou University)H-Index: 8
view all 11 authors...
3 CitationsSource
#1Yuan Liu (YZU: Yangzhou University)H-Index: 9
#2Ziwen Tong (YZU: Yangzhou University)H-Index: 2
Last. Zhiqiang Wang (YZU: Yangzhou University)H-Index: 8
view all 6 authors...
Source
#1Yuan Liu (YZU: Yangzhou University)H-Index: 9
#2Kangni Yang (YZU: Yangzhou University)H-Index: 3
Last. Zhiqiang Wang (YZU: Yangzhou University)H-Index: 8
view all 6 authors...
Purpose Bacterial metabolism regulators offer a novel productive strategy in the eradication of antibiotic refractory bacteria, particularly bacterial persisters. However, the potential of amino acids in the fight against Gram-negative bacterial persisters has not been fully explored. The aim of this study is to investigate the potentiation of amino acids to antibiotics in combating Gram-negative bacterial persisters and to reveal the underlying mechanisms of action. Methods Bactericidal activit...
2 CitationsSource