Yongjian Gao
Systems biologyMass spectrometryChemistryPeroxisome proliferator-activated receptorRadixIn vivoMetabolomicsAlkaloidBile acidActive componentsProtein degradationElectrospray ionizationChromatographyActive ingredientExtraction (chemistry)Lipid metabolismSignal transductionMechanism (biology)Pharmacology
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#1Moying Li (SJTU: Shanghai Jiao Tong University)H-Index: 3
#2Yongjian GaoH-Index: 1
Last. Tong WuH-Index: 1
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Abstract Systems biology is an approach that employs modern biological techniques and methods to combine the overall regulation of the body by Chinese herbal formulas with systems analysis at the molecular level. In this study, the underlying immunomodulatory mechanisms of yupingfeng granules (YPFG) were investigated based on the integration of metabolomics and network pharmacology methods. Selected routine peripheral blood indicators, body weight, and organ indices related to immunity were firs...
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#1Moying Li (SJTU: Shanghai Jiao Tong University)H-Index: 3
#2Xinyi YueH-Index: 1
Last. Tong WuH-Index: 1
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Yupingfeng granules (YPFG) were isolated from a traditional Chinese medicine (TCM) formulation composed of three herbs (Astragali Radix, Atractylodis Macrocephalae Rhizoma, and Saposhnikoviae Radix). This formulation is used in TCM to tonify qi, and it can help strengthen exterior and reduce sweating. Nevertheless, the active components of YPFG remain unclear. In this study, the chemical constituents of YPFG were systematically characterized by ultra-performance liquid chromatography coupled wit...
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