Paola Mattiolo
University of Verona
Survival analysisCancerInternal medicinePathologyOncologyPrognostic variableChromatin remodelingTelomereStage (cooking)KinaseSignet ring cellImmunohistochemistryWild typePathologicalDysplasiaBiliary tractOsteoclastSurvival rateIntraductal papillary mucinous neoplasmAdenosquamous carcinomaMedullary carcinomaMSH6ATRXCD117SNAI2GallbladderAdenomaCarcinomaImmunotherapyTubular adenomaPancreatic tumorPancreatoblastomaPMS2PancreasMetastasisNeuroendocrine tumorsMSH2DiseaseMicrosatellite instabilityPancreatic cancerCDKN2ANeoplasmDifferential diagnosisPD-L1AdenocarcinomaKRASHyperplastic PolypExtrahepatic Bile DuctsGlandular DifferentiationPapillary NeoplasmPancreatic ductal adenocarcinomaPotential biomarkersUndifferentiated carcinomaHeterogeneous groupUnknown primaryCancer researchColorectal cancerMAPK/ERK pathwayDNA mismatch repairMedicineMolecular pathologyBiomarker (medicine)Epithelial–mesenchymal transitionGiant cellNODALBiologyDeath-associated protein 6Mechanism (biology)
Publications 10
#1Claudio LuchiniH-Index: 31
#2Rita T. LawlorH-Index: 31
Last. Aldo ScarpaH-Index: 99
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PURPOSE OF REVIEW Alternative lengthening of telomeres (ALT) is a telomerase-independent mechanism used by some types of malignancies, including pancreatic neuroendocrine tumors, to overcome the issue of telomere shortening, thus supporting tumor growth and cell proliferation. This review is focused on the most important achievements and opportunities deriving from ALT assessment in PanNET onco-pathology, highlighting the most promising fields in which such biomarker could be implemented in clin...
#1Rita T. LawlorH-Index: 31
#2Paola MattioloH-Index: 3
Last. Roberto SalviaH-Index: 52
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Tumor mutational burden (TMB) is a numeric index that expresses the number of mutations per megabase (muts/Mb) harbored by tumor cells in a neoplasm. TMB can be determined using different approaches based on next-generation sequencing. In the case of high values, it indicates a potential response to immunotherapy. In this systematic review, we assessed the potential predictive role of high-TMB in pancreatic ductal adenocarcinoma (PDAC), as well as the histo-molecular features of high-TMB PDAC. H...
Colorectal cancer (CRC) with microsatellite instability (MSI) accounts for 15-18 % of all CRCs and represents the category with the best prognosis. This study aimed at determining any possible clinical/pathological features associated with a higher risk of nodal metastasization in MSI-CRC, and at defining any possible prognostic moderators in this setting. All surgically resected CRCs of the last 20 years (mono-institutional series) with a PCR-based diagnosis of MSI, with and without nodal metas...
#1Giada MunariH-Index: 8
#2Gianluca Businello (UNIPD: University of Padua)H-Index: 3
Last. Matteo FassanH-Index: 62
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PURPOSE Non-neuroendocrine neoplasms of the appendix are a phenotypically heterogeneous group of lesions; a comprehensive molecular characterization of these tumors is still lacking. METHODS A total of 52 samples taken from 49 patients was evaluated: 18 sessile serrated lesions (SSL; 3 with dysplasia), 2 high-grade tubular adenomas, 1 tubulo-villous adenoma,1 hyperplastic polyp, 18 low-grade appendiceal mucinous neoplasms (LAMN), 3 high-grade appendiceal mucinous neoplasms (HAMN) and 9 mucinous ...
#1Claudio LuchiniH-Index: 31
#2Giuseppe PelosiH-Index: 69
Last. Silvia UccellaH-Index: 25
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Neuroendocrine neoplasms of the pancreatobiliary tract and liver are a heterogeneous group that encompass a spectrum of entities with distinct morphological, biological and clinical features. Although in the various anatomical sub-sites of this region they show specific characteristics, these tumors, as a whole, share several etiological and clinical aspects. This review systematically addresses NENs arising in the extrahepatic bile ducts, gallbladder, liver and pancreas, with the principal aim ...
2 CitationsSource
#1Paola MattioloH-Index: 3
#2Giulia FiadoneH-Index: 3
Last. Claudio LuchiniH-Index: 31
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Undifferentiated carcinoma (UC) and undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) are peculiar variants of pancreatic ductal adenocarcinoma (PDAC), characterized by hypercellularity and absence of glandular patterns. The inflammatory microenvironment is peculiar in UCOGC, since it is dominated by macrophages and osteoclast-like giant cells. However, from a molecular point of view, both UC and UCOGC are very similar to conventional PDAC, sharing alterations of the most commo...
6 CitationsSource
#1Chiara BazzichettoH-Index: 9
#2Claudio LuchiniH-Index: 31
Last. Michele Milella (University of Verona)H-Index: 50
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To date, pancreatic cancer is still one of the most lethal cancers in the world, mainly due to the lack of early diagnosis and personalized treatment strategies. In this context, the possibility and the opportunity of identifying genetic and molecular biomarkers are crucial to improve the feasibility of precision medicine. In 2019, the World Health Organization classified pancreatic ductal adenocarcinoma cancer (the most common pancreatic tumor type) into eight variants, according to specific hi...
5 CitationsSource
#1Claudio Luchini (University of Verona)H-Index: 31
#2Gaetano Paolino (University of Verona)H-Index: 3
Last. Aldo Scarpa (University of Verona)H-Index: 99
view all 15 authors...
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease, whose main molecular trait is the MAPK pathway activation due to KRAS mutation, which is present in 90% of cases. The genetic landscape of KRAS wild type PDAC can be divided into three categories. The first is represented by tumors with an activated MAPK pathway due to BRAF mutation that occur in up to 4% of cases. The second includes tumors with microsatellite instability (MSI) due to defective DNA mismatch repair (dMMR), which occurs...
8 CitationsSource
#1Claudio LuchiniH-Index: 31
#2Federica GrilloH-Index: 25
Last. Aldo Scarpa (University of Verona)H-Index: 99
view all 16 authors...
Pancreatic malignant exocrine tumors represent the most important cause of cancer-related death for pancreatic neoplasms. The most common tumor type in this category is represented by pancreatic ductal adenocarcinoma (PDAC), an ill defined, stroma-rich, scirrhous neoplasm with glandular differentiation. Here we present the relevant characteristics of the most important PDAC variants, namely adenosquamous carcinoma, colloid carcinoma, undifferentiated carcinoma, undifferentiated carcinoma with os...
1 CitationsSource
#1Paola Mattiolo (University of Verona)H-Index: 3
#2Seung-Mo Hong (Asan Medical Center)H-Index: 59
Last. Claudio Luchini (University of Verona)H-Index: 31
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The intraductal oncocytic papillary neoplasm (IOPN) of the pancreas has been recognized by WHO classification as a unique intraductal papillary mucinous neoplasm (IPMN) category. IOPN is composed of oxyphil cells, usually expressing MUC5AC, MUC6, and Hep Par-1, and harboring PRKACA/B fusion genes as their genetic hallmark. Although IOPNs are associated with an infiltrative adenocarcinoma in up to 30% of cases, the survival rate after surgical resection approaches 100%. This highlights the import...
3 CitationsSource