Nikita M. Shepelev
Moscow State University
Protein subunitFunction (biology)EnzymeChemistrySaccharomyces cerevisiaeDNARNARibonucleoproteinTelomeraseCell biology
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#1Nikita M. Shepelev (MSU: Moscow State University)
#2Sofia S. Mariasina (MSU: Moscow State University)H-Index: 3
Last. Vladimir I. Polshakov (MSU: Moscow State University)H-Index: 19
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Telomerase is a ribonucleoprotein enzyme, which maintains genome integrity in eukaryotes and ensures continuous cellular proliferation. Telomerase holoenzyme from the thermotolerant yeast Hansenula polymorpha, in addition to the catalytic subunit (TERT) and telomerase RNA (TER), contains accessory proteins Est1 and Est3, which are essential for in vivo telomerase function. Here we report the high-resolution structure of Est3 from Hansenula polymorpha (HpEst3) in solution, as well as the characte...
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