Stela McLachlan
University of Edinburgh
Genome-wide association studyInternal medicineEndocrinologyBlood lipidsDemographySingle-nucleotide polymorphismOdds ratioCardiologyType 2 diabetesInsulin resistanceCholesterolCoronary artery diseaseHuman heightBody mass indexPCSK9PopulationPooled analysisDiabetes mellitusMedicineConfoundingBlood pressureBiology
Publications 26
#1Alistair L. Carr (Edin.: University of Edinburgh)
#2Anniek J. Sluiman (Edin.: University of Edinburgh)H-Index: 1
Last. Jackie F. Price (Edin.: University of Edinburgh)H-Index: 4
view all 7 authors...
Aims/hypothesis We aimed to determine the association of depression with dementia risk in people with type 2 diabetes, and to explore the possible mediating role of inflammation in this relationship. Methods The Edinburgh Type 2 Diabetes Study is a prospective cohort of 1066 men and women with type 2 diabetes aged 60-75 years. Cox proportional hazards regression analysis was used to investigate the association between depression, assessed at baseline, and subsequent risk of dementia over 10 year...
#1Vasiliki Lagou (University of Oxford)H-Index: 26
#2Reedik Mägi (UT: University of Tartu)H-Index: 88
Last. Inga ProkopenkoH-Index: 89
view all 204 authors...
Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic component underlying this phenomenon is not established. We assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) and sex-combined (151,188/105,056 individuals) fasting glucose/fasting insulin genetic effects via genome-wide association stu...
15 CitationsSource
#1Sheila M. Grecian (Edin.: University of Edinburgh)H-Index: 2
#2Stela McLachlan (Edin.: University of Edinburgh)H-Index: 14
Last. Mark W. J. Strachan (Western General Hospital)H-Index: 46
view all 14 authors...
BACKGROUND The incidence of cirrhosis and hepatocellular carcinoma (HCC) is increased in Type 2 diabetes, primarily secondary to non-alcoholic fatty liver disease (NAFLD). European guidelines recommend screening for NAFLD in Type 2 diabetes. American guidelines, while not advocating a screening protocol, suggest using non-invasive markers of fibrosis for risk-stratification and guiding onward referral. AIMS To test the ability of individual fibrosis scores and the European screening algorithm to...
2 CitationsSource
#1Martin BahlsH-Index: 14
#2Matthias W. Lorenz (Goethe University Frankfurt)H-Index: 32
Last. Simon G. Thompson (University of Cambridge)H-Index: 119
view all 55 authors...
AIMS Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. METHODS AND RESULTS An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with futur...
4 CitationsSource
#1Cristina TaddeiH-Index: 15
#2Rod JacksonH-Index: 54
Last. Wenhua ZhaoH-Index: 26
view all 361 authors...
Background Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries. Methods We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and no...
17 CitationsSource
#1Cristina TaddeiH-Index: 15
#2Rod JacksonH-Index: 54
Last. Wenhua ZhaoH-Index: 26
view all 361 authors...
#1Amand F. Schmidt (UCL: University College London)H-Index: 14
#2Michael V. Holmes (University of Oxford)H-Index: 52
Last. Aroon D. Hingorani (UCL: University College London)H-Index: 117
view all 165 authors...
Background We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9.
8 CitationsSource
#1Nora Franceschini (UNC: University of North Carolina at Chapel Hill)H-Index: 74
#2Claudia Giambartolomei (UCLA: University of California, Los Angeles)H-Index: 22
Last. Christopher J. O'Donnell (Harvard University)H-Index: 170
view all 158 authors...
Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Coloc...
54 CitationsSource
#1Milton Fabian Suárez-Ortegón (University of Valle)H-Index: 9
#2Eduardo Ensaldo-Carrasco (Edin.: University of Edinburgh)H-Index: 5
Last. Sarah H. Wild (Edin.: University of Edinburgh)H-Index: 87
view all 6 authors...
Abstract Background and aims Mechanisms for the association between iron stores and risk factors for diabetes and cardiovascular disease, such as metabolic syndrome (MetS) and its components, are still not clear. We evaluated the associations between ferritin levels, MetS and its individual components, and potential role of confounding, in a meta-analysis. Methods We searched articles in MEDLINE and EMBASE until February 14th, 2018. There were two approaches: meta-analysis of 1) cross-sectional ...
23 CitationsSource
#1Majid Ezzati (Imperial College London)H-Index: 138
#2Bin Zhou (Imperial College London)H-Index: 26
Last. Julio Zuniga CisnerosH-Index: 10
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Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood press...
39 CitationsSource