Roberto Alejandro Cruz
University of Texas at Austin
MoleInternal medicineEvidence-based practiceOncologyDermatologyRandomized controlled trialPolitical scienceIntensive care medicinePediatricsRheumatologyMultidisciplinary approachOptic neuritisConnective tissue diseaseSpectrum disorderImmunotherapyLungCollapse (medical)Monoclonal antibody therapyVaccine failureCD19AlemtuzumabDiseaseMEDLINERespiratory tractContext (language use)AutoimmunityTrigeminal neuralgiaMultiple sclerosisRituximabIntervention (counseling)PanicNatalizumabMethotrexateNeuromyelitis opticaRegimenPopulationNeuromyelitis Optica Spectrum DisordersCase conferenceNeurology clinicDisease processFacial painSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Clinical courseResistance (psychoanalysis)Public relationsAdversaryMonoclonal antibodyMedicineImmune systemPandemic
9Publications
4H-index
45Citations
Publications 10
Newest
Abstract The COVID-19 pandemic has devastated individuals, families, and institutions throughout the world. Despite the breakneck speed of vaccine development, the human population remains at risk of further devastation. The decision to not become vaccinated, the protracted rollout of available vaccine, vaccine failure, mutational forms of the SARS virus, which may exhibit mounting resistance to our molecular strike at only one form of the viral family, and the rapid ability of the virus(es) to ...
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#1Roberto Alejandro Cruz (University of Texas at Austin)H-Index: 4
#2Sana Chaudhary (LSU Health Sciences Center New Orleans)
Last. Ethan Meltzer (University of Texas at Austin)H-Index: 5
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Purpose of review To review the pathophysiology, presentation, and treatment of neuromyelitis optica spectrum disorder (NMOSD) and its association with systemic lupus erythematosus (SLE) and Sjogren's syndrome (SS). Recent findings NMOSD is an autoimmune disorder of the central nervous system that primarily targets astrocytes. Although the prevalence is unknown, the coexistence of NMOSD and SLE/SS is well-recognized. Patients with both NMOSD and SLE or SS require may require unique approaches to...
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#2Nick Hogan (University of Texas at Austin)H-Index: 1
Last. Teresa C. FrohmanH-Index: 37
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The patient is a right-handed White woman with relapsing-remitting MS diagnosed subsequent to left acute optic neuritis (AON). She described a previous transient episode of severe, electrical, and paroxysmal facial pain consistent with trigeminal neuralgia. Initial MRI demonstrated supratentorial
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#1Nidhiben Anadani (UR: University of Rochester)
#2Megan HylandH-Index: 5
Last. Teresa Frohman (UR: University of Rochester)H-Index: 1
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A 38-year-old woman with MS receiving natalizumab presented to the neurology clinic with the complaint of a new neurologic symptom. ### Clinical course The patient had a 6-year history of clinically stable MS, albeit exhibiting radiographic progression despite strict adherence to daily
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Objective To determine whether the punctuated administration of low-dose rituximab, temporally linked to B-cell hyperrepopulation (defined when the return of CD19+ B cells approximates 40%–50% of baseline levels as measured before alemtuzumab treatment inception), can mitigate alemtuzumab-associated secondary autoimmunity. Methods In this hypothesis-driven pilot study, 10 patients received low-dose rituximab (50–150 mg/m2), a chimeric anti-CD20 monoclonal antibody, after either their first or se...
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#1Elliot M. Frohman (University of Texas at Austin)H-Index: 84
#2Nicole R. Villemarette-Pittman (LSU Health Sciences Center New Orleans)H-Index: 14
Last. Teresa C. Frohman (University of Texas at Austin)H-Index: 37
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Abstract Here, in Part II of a duology on the characterization and potential treatment for COVID-19, we characterize the application of an innovative treatment regimen for the prevention of the transition from mild to severe COVID-19, as well as detail an intensive immunotherapy intervention hypothesis. We propose as a putative randomized controlled trial that high-dose methotrexate with leucovorin (HDMTX-LR) rescue can abolish ‘PANIC’, thereby ‘left-shifting’ severe COVID-19 patients to the gro...
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#1Elliot M. Frohman (University of Texas at Austin)H-Index: 84
#2Nicole R. Villemarette-Pittman (LSU Health Sciences Center New Orleans)H-Index: 14
Last. Teresa C. Frohman (University of Texas at Austin)H-Index: 37
view all 9 authors...
Abstract The COVID-19 pandemic has produced a world-wide collapse of social and economic infrastructure, as well as constraining our freedom of movement. This respiratory tract infection is unprecedented in that it targets the most distal and highly vulnerable aspect of the human bronchopulmonary tree, specifically, the alveoli that are responsible for the loading of oxygen upon red cell hemoglobin for use by all of the body's tissues. In most symptomatic individuals, the reaction is a productiv...
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#1Edward C. Mader (LSU Health Sciences Center New Orleans)H-Index: 5
#2Alexander B. Ramos (LSU Health Sciences Center New Orleans)H-Index: 3
Last. Lionel A. Branch (LSU Health Sciences Center New Orleans)H-Index: 2
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Toxic leukoencephalopathy (TL) is characterized by white matter disease on magnetic resonance imaging (MRI) and evidence of exposure to a neurotoxic agent. We describe a case of cocaine-induced TL ...
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#1Alexander B. Ramos (LSU Health Sciences Center New Orleans)H-Index: 3
#2Roberto Alejandro Cruz (LSU Health Sciences Center New Orleans)H-Index: 4
Last. Edward C. Mader (LSU Health Sciences Center New Orleans)H-Index: 5
view all 5 authors...
Refractory seizures or status epilepticus (RS/SE) continues to be a challenge in the inpatient setting. Failure to abort a seizure with antiepileptic drugs (AEDs) may lead to intubation and treatment with general anesthesia exposing patients to complications, extending hospitalization, and increasing the cost of care. Studies have shown a key role of inflammatory mediators in seizure generation and termination. We describe 4 patients with RS/SE that was aborted when dexamethasone was added to co...
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