Tinne Goos
Katholieke Universiteit Leuven
PathophysiologyAirwayInternal medicinePathologyDLCORetrospective cohort studyIntensive care medicineStage (cooking)Hazard ratioFEV1/FVC ratioBronchiolitis obliteransObstructive lung diseaseUsual interstitial pneumoniaInterstitial lung diseaseLungIdiopathic pulmonary fibrosisBronchiectasisHoneycombingContext (language use)FibrosisFamily historyPulmonary fibrosisSarcoidosisLung transplantationDonor lungsScoring systemAirway segmentationMultivariate analysisVital capacityGenetic predispositionMedicinePulmonary function testingGastroenterology
6Publications
2H-index
5Citations
Publications 8
Newest
#1Laurens J. De Sadeleer (Katholieke Universiteit Leuven)H-Index: 9
#2John E. McDonough (Yale University)H-Index: 21
Last. Wim Wuyts (Katholieke Universiteit Leuven)H-Index: 38
view all 26 authors...
Rationale null Fibrotic hypersensitivity pneumonitis (fHP) is an interstitial lung disease caused by sensitization to an inhaled allergen. null Objectives null We aimed to identify the molecular determinants associated with progression of fibrosis. null Methods null Nine fHP explant lungs and six unused donor lungs (as controls) were systematically sampled (4 samples/lung). According to microCT measures, fHP cores were clustered into a mild, moderate and severe fibrosis group. Gene expression pr...
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#1Tinne Goos (Katholieke Universiteit Leuven)H-Index: 2
#2Laurens J. De Sadeleer (Katholieke Universiteit Leuven)H-Index: 9
Last. Robin Vos (Katholieke Universiteit Leuven)H-Index: 42
view all 13 authors...
Abstract null null Randomized placebo-controlled trials demonstrated the efficacy of antifibrotic treatment in non-IPF progressive fibrosing ILD (fILD). Currently, there is no consensus on how progression should be defined and clinical data of non-IPF fILD patients in a real-world setting are scarce. null Non-IPF fILD patients presenting at the University Hospitals Leuven between 2012 and 2016 were included. Different definitions of progression according to the selection criteria of the INBUILD,...
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Purpose Post-infectious bronchiolitis obliterans (PIBO) forms a chronic obstructive lung disease in children following a severe viral respiratory infection. Subsequent dysanaptic lung growth, with differential development of the alveolar compartment over the airway compartment, was clinically described, but remains elusive. We therefore performed a detailed 3D airway characterization in PIBO compared to bronchiolitis obliterans syndrome (BOS) after lung transplantation and discarded donor lungs....
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#1Tinne GoosH-Index: 2
Last. Wim Wuyts (Katholieke Universiteit Leuven)H-Index: 38
view all 7 authors...
A significant proportion of patients with interstitial lung disease (ILD) may develop a progressive fibrosing phenotype characterized by worsening of symptoms and pulmonary function, progressive fibrosis on chest computed tomography and increased mortality. The clinical course in these patients mimics the relentless progressiveness of idiopathic pulmonary fibrosis (IPF). Common pathophysiological mechanisms such as a shared genetic susceptibility and a common downstream pathway—self-sustaining f...
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#1Stijn E. Verleden (Katholieke Universiteit Leuven)H-Index: 38
#2Arno Vanstapel (Katholieke Universiteit Leuven)H-Index: 7
Last. Wim Wuyts (Katholieke Universiteit Leuven)H-Index: 38
view all 16 authors...
ABSTRACT Background Sarcoidosis is a systemic granulomatous disease that in most cases affects the lung. Pulmonary fibrotic sarcoidosis is clinically, radiologically and pathologically a heterogeneous condition. Although there is substantial indirect evidence of small airway involvement, direct evidence is currently lacking. Research question to investigate the role of the (small) airways in fibrotic sarcoidosis. Study design and methods: Airway morphology was investigated in 7 explant lungs wit...
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#1Tinne GoosH-Index: 2
Last. Wim WuytsH-Index: 38
view all 8 authors...
Background: Familial pulmonary fibrosis (FPF) is a rare condition defined by the presence of at least two first line-relatives with interstitial lung disease (ILD) in one family. The aim of this study was to compare transplant-free survival outcomes from familial IPF (f-IPF) and sporadic IPF (s-IPF) patients. Methods: Clinical characteristics of all IPF patients referred for multidisciplinary expert discussion between 2005 and 2018 were retrospectively collected. Patients were stratified accordi...
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#1Laurens J. De Sadeleer (Katholieke Universiteit Leuven)H-Index: 9
#2Tinne Goos (Katholieke Universiteit Leuven)H-Index: 2
Last. Wim Wuyts (Katholieke Universiteit Leuven)H-Index: 38
view all 4 authors...
Although only recently introduced in the ILD community, the concept of progressive fibrosing interstitial lung disease (PF-ILD) has rapidly acquired an important place in the management of non-idiopathic pulmonary fibrosis fibrosing ILD (nonIPF fILD) patients. It confirms a clinical gut feeling that an important subgroup of nonIPF fILD portends a dismal prognosis despite therapeutically addressing the alleged triggering event. Due to several recently published landmark papers showing a treatment...
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