Philipp Uhl
University Hospital Heidelberg
BiophysicsInternal medicineMolecular imagingNanoparticleNanotechnologyBioavailabilityNanocarriersLiposomeChemistryIn vitroImmunologyIn vivoCell-penetrating peptideHepatitis BVancomycinPeptideDrug deliveryDrugBiochemistryDrug developmentMedicineZeta potentialPharmacology
19Publications
7H-index
182Citations
Publications 19
Newest
#1Anna Pratsinis (University of Basel)
#2Philipp Uhl (University Hospital Heidelberg)H-Index: 7
Last. Jörg Huwyler (University of Basel)H-Index: 49
view all 9 authors...
Recently, a lipopeptide derived from the hepatitis B virus (HBV) large surface protein has been developed as an HBV entry inhibitor. This lipopeptide, called MyrcludexB (MyrB), selectively binds to the sodium taurocholate cotransporting polypeptide (NTCP) on the basolateral membrane of hepatocytes. Here, the feasibility of coupling therapeutic enzymes to MyrB was investigated for the development of enzyme delivery strategies. Hepatotropic targeting shall enable enzyme prodrug therapies and detox...
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#1Philipp Uhl (University Hospital Heidelberg)H-Index: 7
#2Max Sauter (University Hospital Heidelberg)H-Index: 6
Last. Elisa Hopke (University of Würzburg)
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#1Julia Benzel (DKFZ: German Cancer Research Center)H-Index: 2
#1Julia Benzel (DKFZ: German Cancer Research Center)H-Index: 5
Last. Kristian W. Pajtler (DKFZ: German Cancer Research Center)H-Index: 26
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Introduction: The majority of pediatric supratentorial (ST) ependymomas (EPN) is driven by distinct gene fusions between C11orf95 and RELA. The resultant molecular group of ST-EPN-RELA tumors is characterized by constitutive activation of NF-κB signaling and deregulation of the p53 pathway. In contrast to surgery and radiotherapy, chemotherapy has failed to demonstrate significant benefit in the management of affected children. Alternative strategies including enhanced drug delivery, combination...
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#1Florian UmstätterH-Index: 2
#2Cornelius DomhanH-Index: 4
Last. Philipp UhlH-Index: 7
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#1Florian UmstätterH-Index: 2
#2Cornelius DomhanH-Index: 4
Last. Philipp UhlH-Index: 7
view all 12 authors...
1 CitationsSource
#1Florian Umstätter (University Hospital Heidelberg)
#1Florian UmstätterH-Index: 2
Last. Philipp UhlH-Index: 7
view all 12 authors...
Source
#1Florian Umstätter (University Hospital Heidelberg)
#1Florian UmstätterH-Index: 2
Last. Philipp UhlH-Index: 7
view all 12 authors...
Source
#1Philipp Uhl (University Hospital Heidelberg)H-Index: 7
#2C. Grundmann (University Hospital Heidelberg)H-Index: 1
Last. Walter Mier (University Hospital Heidelberg)H-Index: 63
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Abstract Until today, the oral delivery of peptide drugs is hampered due to their instability in the gastrointestinal tract and low mucosal penetration. To overcome these hurdles, PLA (polylactide acid)-nanoparticles were coated with a cyclic, polyarginine-rich, cell penetrating peptide (cyclic R9-CPP). These surface-modified nanoparticles showed a size and polydispersity index comparable to standard PLA-nanoparticles. The zeta potential showed a significant increase indicating successful CPP-co...
15 CitationsSource
#1Dominik Witzigmann (University of Basel)H-Index: 16
#2Philipp Uhl (University Hospital Heidelberg)H-Index: 7
Last. Jörg Huwyler (University of Basel)H-Index: 49
view all 16 authors...
: Active targeting and specific drug delivery to parenchymal liver cells is a promising strategy to treat various liver disorders. Here, we modified synthetic lipid-based nanoparticles with targeting peptides derived from the hepatitis B virus large envelope protein (HBVpreS) to specifically target the sodium-taurocholate cotransporting polypeptide (NTCP; SLC10A1) on the sinusoidal membrane of hepatocytes. Physicochemical properties of targeted nanoparticles were optimized and NTCP-specific, lig...
11 CitationsSource
#1Sandro Sieber (University of Basel)H-Index: 9
#2Philip Grossen (University of Basel)H-Index: 8
Last. Jörg Huwyler (University of Basel)H-Index: 49
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Abstract Macrophage recognition of nanoparticles is highly influenced by particle size and surface modification. Due to the lack of appropriate in vivo screening models, it is still challenging and time-consuming to characterize and optimize nanomedicines regarding this undesired clearance mechanism. Therefore, we validate zebrafish embryos as an emerging vertebrate screening tool to assess the macrophage sequestration of surface modified particulate formulations with varying particle size under...
21 CitationsSource