Tomohiro Shirayanagi
Chiba University
Genetically modified mouseCellCytotoxic T cellVirologyAntibodyChemistryPhage displayHuman leukocyte antigenImmunologyAnimal modelPeptideAbacavirHaptenDrug toxicityBiology
Publications 2
#1Takeshi Susukida (University of Toyama)H-Index: 5
#1Takeshi Susukida (University of Toyama)
Last. Kousei Ito (Chiba University)H-Index: 29
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Various types of transgenic mice carrying either class I or II human leukocyte antigen (HLA) molecules are readily available, and reports describing their use in a variety of studies have been publ...
1 CitationsSource
#1Tomohiro Shirayanagi (Chiba University)H-Index: 1
#2Shigeki Aoki (Chiba University)H-Index: 7
Last. Kousei Ito (Chiba University)H-Index: 29
view all 9 authors...
The interaction of human leukocyte antigen (HLA) with specific drugs is associated with delayed-type hypersensitivity reactions, which cause severe cutaneous toxicity. Such interactions induce structural alterations in HLA complexes via several different mechanisms such as the hapten theory, p-i concept, and altered peptide repertoire model, leading to the activation of cytotoxic T cells. To date, comprehensive detection of such structural alterations in preclinical studies has been difficult. H...
1 CitationsSource