Guizhen Zhao
University of Michigan
Endothelial stem cellInternal medicineDownregulation and upregulationTFEBCellChemistryApoptosisInflammationEndotheliumCholesterolCytokineMacrophageVascular smooth muscleAbdominal aortic aneurysmCancer researchDiabetes mellitusMedicineBeta oxidationTranscription factorBiology
9Publications
3H-index
24Citations
Publications 9
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#1Guizhen Zhao (UM: University of Michigan)H-Index: 3
#2Haocheng Lu (UM: University of Michigan)H-Index: 8
Last. Jifeng Zhang (UM: University of Michigan)H-Index: 36
view all 10 authors...
AIMS The artery contains numerous cell types which contribute to multiple vascular diseases. However, the heterogeneity and cellular responses of these vascular cells during abdominal aortic aneurysm (AAA) progression have not been well characterized. METHODS AND RESULTS Single-cell RNA sequencing (scRNA-seq) was performed on the infrarenal abdominal aortas from C57BL/6J mice at days 7 and 14 post-sham or peri-adventitial elastase-induced AAA. Unbiased clustering analysis of the transcriptional ...
3 CitationsSource
#1Guizhen Zhao (UM: University of Michigan)H-Index: 3
#2Ziyi Chang (UM: University of Michigan)H-Index: 4
Last. Jifeng Zhang (UM: University of Michigan)H-Index: 36
view all 16 authors...
Abdominal aortic aneurysm (AAA) is a life-threatening degenerative vascular disease. Endothelial cell (EC) dysfunction is implicated in AAA. Our group recently demonstrated that Kruppel-like factor 11 (KLF11) plays an essential role in maintaining vascular homeostasis, at least partially through inhibition of EC inflammatory activation. However, the functions of endothelial KLF11 in AAA remain unknown. Here we found that endothelial KLF11 expression was reduced in the ECs from human aneurysms an...
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#1Jinjian Sun (UM: University of Michigan)H-Index: 3
#2Haocheng Lu (UM: University of Michigan)H-Index: 8
Last. Yanbo Fan (UM: University of Michigan)H-Index: 21
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Objective: Vascular endothelial cells (ECs) play a critical role in maintaining vascular homeostasis. Aberrant EC metabolism leads to vascular dysfunction and metabolic diseases. TFEB (transcriptio...
3 CitationsSource
#1Oren Rom (UM: University of Michigan)H-Index: 15
#2Yuhao Liu (UM: University of Michigan)H-Index: 4
Last. Y. Eugene Chen (UM: University of Michigan)H-Index: 57
view all 33 authors...
Nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH) has reached epidemic proportions with no pharmacological therapy approved. Lower circulating glycine is consistently reported in patients with NAFLD, but the causes for reduced glycine, its role as a causative factor, and its therapeutic potential remain unclear. We performed transcriptomics in livers from humans and mice with NAFLD and found suppression of glycine biosynthetic genes, primarily alanine-glyoxyl...
5 CitationsSource
#1Ziyi Chang (UM: University of Michigan)H-Index: 4
#2Guizhen Zhao (UM: University of Michigan)H-Index: 3
Last. Jifeng Zhang (UM: University of Michigan)H-Index: 36
view all 18 authors...
OBJECTIVE Currently, there are no approved drugs for abdominal aortic aneurysm (AAA) treatment, likely due to limited understanding of the primary molecular mechanisms underlying AAA development and progression. BAF60a-a unique subunit of the SWI/SNF (switch/sucrose nonfermentable) chromatin remodeling complex-is a novel regulator of metabolic homeostasis, yet little is known about its function in the vasculature and pathogenesis of AAA. In this study, we sought to investigate the role and under...
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#1Haocheng Lu (UM: University of Michigan)H-Index: 8
#2Jinjian Sun (UM: University of Michigan)H-Index: 3
Last. Yanbo Fan (UM: University of Michigan)H-Index: 21
view all 16 authors...
Background: Abdominal aortic aneurysm (AAA) is a severe aortic disease with a high mortality rate in the event of rupture. Pharmacological therapy is needed to inhibit AAA expansion and prevent ane...
11 CitationsSource
#1Yang Zhao (UM: University of Michigan)H-Index: 2
#2Ziyi Chang (UM: University of Michigan)H-Index: 4
Last. Y. Eugene Chen (UM: University of Michigan)H-Index: 57
view all 17 authors...
PURPOSE Abdominal aortic aneurysm (AAA) is one of the leading causes of death in the developed world and is currently undertreated due to the complicated nature of the disease. Herein, we aimed to address the therapeutic potential of a novel class of pleiotropic mediators, specifically a new drug candidate, nitro-oleic acid (NO2-OA), on AAA, in a well-characterized murine AAA model. METHODS We generated AAA using a mouse model combining AAV.PCSK9-D377Y induced hypercholesterolemia with angiotens...
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Background: Endothelial Cell (EC) dysfunction contributes to many vascular diseases. Kruppel like factor 11 (KLF11), a transcription factor involved in diabetes, inhibits EC inflammation via regula...