Koichiro Yamamoto
Okayama University
Messenger RNAProcalcitoninPhosphorylationInternal medicineRadiologyDownregulation and upregulationEndocrinologyPathologyVirologyReceptorCLOCKChemistryLiver receptor homolog-1Acute pancreatitisInflammationHemoglobinForskolinGlucocorticoid2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Polycystic ovaryBone morphogenetic proteinDiabetes mellitusGlucocorticoid receptorClinical significanceHormoneText miningMedicineCholesterol side-chain cleavage enzymeBiologyGastroenterologyCell biology
22Publications
2H-index
2Citations
Publications 21
Newest
#1Atsuhito Suyama (Okayama University)H-Index: 1
#2Nahoko Iwata (Okayama University)H-Index: 5
Last. Fumio Otsuka (Okayama University)H-Index: 35
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The functional role of the transcription factors NR5A1 and NR5A2 and their interaction with Clock gene and bone morphogenetic proteins (BMPs) were investigated in human granulosa KGN cells. Treatment with BMP-15 and GDF-9 suppressed forskolin (FSK)-induced steroidogenesis as shown by the mRNA expression levels of StAR and P450scc but not the mRNA expression level of P450arom. Of interest, treatment with BMP-15 and GDF-9 also suppressed FSK-induced NR5A2 mRNA expression. Treatment with BMP-15 sup...
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#1Koichiro Yamamoto (Okayama University)H-Index: 2
#2Kosuke Oka (Okayama University)H-Index: 2
Last. Fumio Otsuka (Okayama University)H-Index: 35
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Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis, involving multiple organs. We report a case of ECD with typical features of an orbital mass and "hairy kidneys," whose recognition can lead to early diagnosis and treatment.
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#1Jo Araki (Okayama University)
#2Kosuke Oka (Okayama University)H-Index: 2
Last. Fumio Otsuka (Okayama University)H-Index: 35
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Various laboratory markers of inflammation are utilized in general practice, but their clinical diagnostic significance is often ambiguous. In the present study, we determined the clinical significance of the examination of serum levels of procalcitonin (PCT) by comparing the PCT levels with the levels of other inflammatory markers, based on a retrospective review of 332 PCT-positive patients, including cases of bacterial infection (20.5%), non-specific inflammation (20.8%), neoplasm (9.9%), con...
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We report a case of isolated adrenocorticotropin deficiency caused by pembrolizumab. This condition can be fatal, but its rarity causes under-recognition. Oncologists should pay attention to adrenal insufficiency due to pembrolizumab.
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#1Shuichi Tanaka (Okayama University)
#2Koichiro Yamamoto (Okayama University)H-Index: 2
Last. Fumio Otsuka (Okayama University)H-Index: 35
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#1Koichiro Yamamoto (Okayama University)H-Index: 2
#2Kosuke Oka (Okayama University)H-Index: 2
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 4 authors...
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#1Chiaki Kashino (Okayama University)H-Index: 1
#2Toru Hasegawa (Okayama University)H-Index: 4
Last. Fumio Otsuka (Okayama University)H-Index: 35
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To elucidate the impact of glucocorticoids on ovarian steroidogenesis and its molecular mechanism by focusing on bone morphogenetic proteins (BMPs), we examined the effect of dexamethasone (Dex) on estradiol and progesterone synthesis by using primary culture of rat granulosa cells. It was revealed that Dex treatment dose-dependently decreased estradiol production but increased progesterone production induced by follicle-stimulating hormone (FSH) by granulosa cells. In accordance with the effect...
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#1Kosuke Oka (Okayama University)H-Index: 2
#2Jo Araki (Okayama University)
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 9 authors...
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#1Atsuhito Suyama (Okayama University)H-Index: 1
#2Nahoko Iwata (Okayama University)H-Index: 5
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 7 authors...
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