Jonas Oldgren
Uppsala University Hospital
Troponin IInternal medicineSurgeryCardiologyIntensive care medicineWarfarinHeparinAcute coronary syndromeAnticoagulantCoronary artery diseaseChest painDabigatranAtrial fibrillationInogatranPercutaneous coronary interventionIn patientTroponinAnesthesiaMyocardial infarctionStrokeMedicine
37Publications
14H-index
804Citations
Publications 38
Newest
#1Jonas Oldgren (Uppsala University Hospital)H-Index: 14
#1Ulrica Alström (Uppsala University Hospital)H-Index: 5
#2Fredrik Granath (KI: Karolinska Institutet)H-Index: 94
Last. Agneta Siegbahn (Uppsala University Hospital)H-Index: 85
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INTRODUCTION: A substantial number of patients with coronary artery disease undergo cardiac surgery within five days of discontinuing anti-platelet treatment with aspirin and clopidogrel. The aims ...
37 CitationsSource
#1Kai M. Eggers (Uppsala University Hospital)H-Index: 13
#2Bo Lagerqvist (Uppsala University Hospital)H-Index: 50
Last. Bertil Lindahl (Uppsala University Hospital)H-Index: 83
view all 6 authors...
Background Recently, a high prevalence of small persistent cardiac troponin I (cTnI) elevations has been reported in patients who had been stabilized after a recent episode of acute coronary syndrome (ACS). We now have studied the associations of persistently elevated cTnI levels to cardiac performance, inflammation, coagulation, coronary status, and treatment strategy in these patients. Methods and Results Cardiac troponin I was determined at 6 weeks, 3 months, and 6 months after randomization ...
19 CitationsSource
#1Kai M. Eggers (Uppsala University Hospital)H-Index: 13
#2Mikael Dellborg (Sahlgrenska University Hospital)H-Index: 52
Last. Bertil LindahlH-Index: 83
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Abstract Background Early risk stratification of patients with chest pain may be improved by combining cardiac Troponin I (cTnI) results and ECG findings with markers of left-ventricular dysfunction, inflammation or renal function. Methods Serial measurements of cTnI were prospectively performed in 452 chest pain patients with a non-diagnostic ECG for AMI and admitted to the coronary care unit. NT-pro BNP, CRP, cystatin C and creatinine-clearance were retrospectively analyzed in admission sample...
12 CitationsSource
#1Jonas Oldgren (Uppsala University Hospital)H-Index: 14
#2Nina Johnston (Uppsala University Hospital)H-Index: 22
Last. Agneta Siegbahn (Uppsala University Hospital)H-Index: 85
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BACKGROUND: We evaluated coagulation activity in relation to gender in patients with acute coronary syndromes and in healthy individuals of similar age, and related coagulation activity to levels of Xa inhibition during dalteparin treatment. METHODS: Serial blood samples were obtained from 555 (172 women) of 2267 patients in the Scandinavian FRISC II study, and a single sample in 457 (151 women) apparently healthy age- and sex-matched individuals. After randomization, all patients received dalte...
5 CitationsSource
#1Jonas Oldgren (Uppsala University Hospital)H-Index: 14
#2Lars Wallentin (Uppsala University Hospital)H-Index: 30
Last. Salim Yusuf (Population Health Research Institute)H-Index: 247
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Aims At least one quarter of ST-segment elevation myocardial infarction (STEMI) patients do not receive reperfusion therapy, and these patients are at high risk for new ischaemic events. We evaluated fondaparinux treatment vs. usual care, i.e. placebo or unfractionated (UF) heparin, in a pre-specified subgroup of 2867 (out of 12 092) patients not receiving reperfusion treatment in the OASIS-6 trial. Methods In all, 1458 patients were randomized to fondaparinux 2.5 mg once daily subcutaneously up...
45 CitationsSource
#1Ron J.G. PetersH-Index: 57
#2Campbell D. Joyner (Sunnybrook Health Sciences Centre)H-Index: 32
Last. Salim Yusuf (Population Health Research Institute)H-Index: 247
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Aims No antithrombotic therapy has been shown to reduce mortality when used with thrombolytics in acute myocardial infarction (AMI). In the OASIS-6 trial, fondaparinux significantly reduced mortality and reinfarction without increasing bleeding in 12 092 patients with acute ST elevation MI. Methods and results We report the results of a subgroup analysis in the 5436 patients (45%) receiving thrombolytics. According to local practice, 4415 patients did not have an indication for unfractionated he...
52 CitationsSource
#1Jonas Oldgren (Uppsala University Hospital)H-Index: 14
#2Stefan James (Uppsala University Hospital)H-Index: 96
Last. Lars Wallentin (Uppsala University Hospital)H-Index: 30
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Aim Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been suggested as an independent predictor of cardiovascular events in epidemiological studies. We sought to evaluate Lp-PLA2 as a risk factor for future cardiovascular events in patients with acute coronary syndromes (ACS) and to elucidate the relationship between Lp-PLA2 and other known risk markers in ACS patients and healthy control subjects. Methods and results Blood samples were obtained at randomization in a random subset of ACS pa...
52 CitationsSource
#1Kai M. Eggers (Uppsala University Hospital)H-Index: 13
#2Johan Ellenius (KI: Karolinska Institutet)H-Index: 6
Last. Bertil LindahlH-Index: 83
view all 7 authors...
Abstract Background To prospectively validate artificial neural network (ANN)-algorithms for early diagnosis of myocardial infarction (AMI) and prediction of ‘major infarct' size in patients with chest pain and without ECG changes diagnostic for AMI. Methods Results of early and frequent Stratus CS measurements of troponin I (TnI) and myoglobin in 310 patients were used to validate four prespecified ANN-algorithms with use of cross-validation techniques. Two separate biochemical criteria for dia...
37 CitationsSource
#1Jonas Oldgren (Uppsala University Hospital)H-Index: 14
#2C. FelleniusH-Index: 3
Last. Agneta Siegbahn (Uppsala University Hospital)H-Index: 85
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Skelleftea Hospital, and Umea University Hospital, Background. Unstable coronary artery disease (CAD) is a multi-factorial disease involving thrombotic and inflammatory processes. Short-term low molecular weight (LMW) heparin treatment reduces coagulation activity and clinical events. We investigated the influence of prolonged treatment on coagulation, fibrinolysis and inflammation. Methods and results. Serial blood samples were obtained from 555 of 2267 unstable CAD patients in the FRISC II stu...
19 CitationsSource