Laura Handgriff
Ludwig Maximilian University of Munich
Quality of lifeSubclinical infectionPsychopathologyInternal medicineUrologyOsteocalcinEndocrinologySurgeryAutoantibodyCardiologyBone remodelingProspective cohort studyMineralocorticoid receptorImmunologyArterial stiffnessObstructive sleep apneaHyperaldosteronismSpironolactoneOsteoporosisEssential hypertensionAdenomaSecondary hypertensionPulse wave velocityAldosteroneDepression (differential diagnoses)DiseaseIntima-media thicknessContext (language use)Single CenterAdrenalectomyPrimary aldosteronismDexamethasone suppression testGlucocorticoidTaste ThresholdGynecologyInternal validationPrediction scoreCortisol secretionOrgan damageSalt intakeIn patientPost surgicalArterielle hypertonieDisease courseTiterAnti-thyroid autoantibodiesSodiumHistopathologyDiabetes mellitusAnxietyBone resorptionMedicineCohortAppetiteBlood pressureTasteGastroenterology
12Publications
2H-index
5Citations
Publications 12
Newest
#1Lucie S. Meyer (LMU: Ludwig Maximilian University of Munich)H-Index: 4
#2Laura Handgriff (LMU: Ludwig Maximilian University of Munich)H-Index: 2
Last. Tracy Ann Williams (LMU: Ludwig Maximilian University of Munich)H-Index: 38
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Unilateral forms of primary aldosteronism are usually surgically treated to remove the source of aldosterone excess. After adrenalectomy, aldosteronism persists in some patients indicating abnormal aldosterone production from the unresected gland. Our objective was to investigate histopathology, genotype, and postsurgical outcomes in a 3-year prospective cohort of surgically treated patients for primary aldosteronism (from 2016 to 2018). The cohort comprised 60 consecutively operated patients ca...
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#2Laura HandgriffH-Index: 2
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#1Jacopo Burrello (UNITO: University of Turin)H-Index: 18
#2Martina Amongero (UNITO: University of Turin)H-Index: 2
Last. Paolo Mulatero (UNITO: University of Turin)H-Index: 52
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Context The diagnostic work-up of primary aldosteronism (PA) includes screening and confirmation steps. Case confirmation is time-consuming, expensive, and there is no consensus on tests and thresholds to be used. Diagnostic algorithms to avoid confirmatory testing may be useful for the management of patients with PA. Objective Development and validation of diagnostic models to confirm or exclude PA diagnosis in patients with a positive screening test. Design, patients and setting We evaluated 1...
1 CitationsSource
#1Christian Adolf (LMU: Ludwig Maximilian University of Munich)H-Index: 8
#2Veronika Görge (LMU: Ludwig Maximilian University of Munich)H-Index: 2
Last. Martin Reincke (LMU: Ludwig Maximilian University of Munich)H-Index: 82
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Rodents exposed to mineralocorticoid excess have considerably decreased taste sensitivity for sodium chloride (NaCl) and show high dietary sodium intake. A similar shift in NaCl taste perception co...
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#1Pauline Gendreitzig (Praxis)H-Index: 1
#2Heike Künzel (LMU: Ludwig Maximilian University of Munich)H-Index: 6
Last. Marcus Quinkler (Praxis)H-Index: 67
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CONTEXT Primary aldosteronism (PA) is associated with impaired quality of life (QoL). Autonomous cortisol co-secretion (ACS) is a relevant phenotype of PA, which could contribute to depression and anxiety disorders. This has not been investigated so far. OBJECTIVE To evaluate the prevalence of depression and anxiety in PA patients according to ACS. METHODS We performed testing for hypercortisolism and evaluated anxiety, depression and QoL by self-rating questionnaires in newly diagnosed PA patie...
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Patients with primary aldosteronism (PA) are at increased cardiovascular risk, compared to patients with essential hypertension (EH). Cardiovascular damage could depend on PA phenotype, potentially being lower in milder forms of PA. Our aim was to assess atherosclerotic burden and arterial stiffness in 88 prospectively recruited patients, including 44 patients with mild PA and EH respectively. All patients underwent a structured study program, including measurements of ankle-brachial index, osci...
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#1Daniel A. HeinrichH-Index: 9
#2Christian AdolfH-Index: 8
Last. Martin ReinckeH-Index: 82
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#1Christian AdolfH-Index: 8
#2Leah T BraunH-Index: 5
Last. Martin ReinckeH-Index: 82
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CONTEXT Primary aldosteronism (PA) is the most frequent form of endocrine hypertension. Besides its deleterious impact on cardiovascular target organ damage, PA is considered to cause osteoporosis. PATIENTS AND METHODS We assessed bone turnover in a subset of 36 postmenopausal women with PA. 18 patients had unilateral PA and were treated by adrenalectomy, whereas 18 patients had bilateral PA and received mineralocorticoid receptor antagonist (MRA) therapy respectively. 18 age- and BMI-matched fe...
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#1Laura Handgriff (LMU: Ludwig Maximilian University of Munich)H-Index: 2
#2Martin Reincke (LMU: Ludwig Maximilian University of Munich)H-Index: 82
Primary aldosteronism (PA) represents the leading cause of endocrine hypertension, accounting for 4-13 % of all cases. Simultaneously, it is the most common endocrine form of hypertension that can be cured by surgery. Estimates suggest that 2.5 million people in Germany are affected, yet only 8 % of hypertensive patients undergo the proper diagnostic screening for PA. The diagnosis of PA is evidently not taken into account sufficiently when it comes to the everyday management of hypertension. Si...
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#1Laura Handgriff (LMU: Ludwig Maximilian University of Munich)H-Index: 2
#2Christian Adolf (LMU: Ludwig Maximilian University of Munich)H-Index: 8
Last. Martin Reincke (LMU: Ludwig Maximilian University of Munich)H-Index: 82
view all 11 authors...
: Excess aldosterone is associated with the increased risk of cardio-/cerebrovascular events as well as metabolic comorbidities not only due to its hypertensive effect but also due to its proinflammatory action. Autonomous cortisol secretion (ACS) in the setting of primary aldosteronism (PA) is known to worsen cardiovascular outcome and potentially exhibit immunosuppressive effects. The aim of this study was to determine the impact of ACS status in patients with PA on kinetics of thyroid autoant...
2 CitationsSource