Gaud Dervilly
Institut national de la recherche agronomique
AnabolismContaminationCollisionRisk assessmentData miningIon-mobility spectrometryMass spectrometryDeconvolutionWorkflowChemistryExposure assessmentHazard analysisMetabolomicsPersistent organic pollutantShotgun lipidomicsNandroloneChlorinated paraffinsUrineContext (language use)LipidomeCharacterization (materials science)LactosylceramideMass spectrometricSerum samplesDietary exposureLong chainFood scienceEnvironmental scienceComputer scienceMatrix decompositionChromatographyChlorineLipidomicsComputational biologyHormoneMedicine
23Publications
8H-index
86Citations
Publications 23
Newest
#1Alastair B. Ross (AgResearch)H-Index: 35
#2Carl Brunius (Chalmers University of Technology)H-Index: 17
Last. Lynn Vanhaecke (UGent: Ghent University)H-Index: 44
view all 14 authors...
Abstract Increasing demands are being placed on meat producers to verify more about their product with regards to safety, quality and authenticity. There are many methods that can detect aspects of these parameters in meat, yet most are too slow to keep up with the demands of modern meat processing plants and supply chains. A new technology, Rapid Evaporative Ionisation Mass Spectrometry (REIMS), has the potential to bridge the gap between advanced laboratory measurements and technology that can...
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#2Marzia PezzolatoH-Index: 11
Last. Elena BozzettaH-Index: 14
view all 9 authors...
Abstract Administering growth promoters to meat-producing animals is strictly regulated within the European Community to preserve consumers’ safety. Nevertheless, illicit misuse of steroids and other veterinary drugs to increase animal production has still been found by National Residues Control Plans (NRCPs), mainly based on expensive targeted multi-class/multi-residue analytical methods, used for confirming quantification analysis of these residues in tissues and biological fluids. The setup o...
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#1Marie MézièreH-Index: 4
#2Philippe MarchandH-Index: 14
Last. Ronan CariouH-Index: 18
view all 7 authors...
Abstract Reliable human health risk assessment associated with chlorinated paraffins (CPs) exposure is limited by the lack of data on the fate of this complex family of contaminants. To gain knowledge on the accumulation and distribution of CPs in biota after ingestion, laying hens were dietary exposed to technical mixtures of short- (SCCPs), medium- (MCCPs), or long-chain (LCCPs) CPs of various chlorine contents during 91 days, at 200 ng/g of feed, each. Adipose tissue, liver, muscle and serum ...
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With the aim of specifically investigating patterns associated with three steroid treatments (17β-nandrolone, 17β-estradiol, and 17β-nandrolone + 17β-estradiol) in bovine, an reversed phase liquid chromatography (RPLC)-electrospray ionization (ESI)(+/-)-high-resolution mass spectrometry (HRMS) study was conducted to characterize the urinary profiles of involved animals. Although specific fingerprints with strong differences could be highlighted between urinary metabolite profiles within urine sa...
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#1Jérémy MarchandH-Index: 3
#2Yann GuittonH-Index: 15
Last. Gaud DervillyH-Index: 8
view all 8 authors...
From a general public health perspective, a strategy combining non-targeted and targeted lipidomics MS-based approaches is proposed to identify disrupted patterns in serum lipidome upon growth promoter treatment in pigs. Evaluating the relative contributions of the platforms involved, the study aims at investigating the potential of innovative analytical approaches to highlight potential chemical food safety threats. Serum samples collected during an animal experiment involving control and treat...
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#1Caroline Simonnet-Laprade (INRA: Institut national de la recherche agronomique)H-Index: 1
#2Stéphane Bayen (McGill University)H-Index: 23
Last. Gaud Dervilly (INRA: Institut national de la recherche agronomique)H-Index: 8
view all 4 authors...
Abstract Thousands of chemicals are potentially contaminating the environment and food resources, covering a wide spectrum of molecular structures, physico-chemical properties, sources, environmental behavior and toxic profiles. Beyond the description of the individual chemicals, characterizing contaminant mixtures in related matrices has become a major challenge in ecological and human health risk assessments. Continuous analytical developments, in the fields of targeted (TA) and non-targeted a...
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#1Marie MézièreH-Index: 4
#2Philippe MarchandH-Index: 14
Last. Ronan CariouH-Index: 18
view all 8 authors...
Abstract Chlorinated paraffins (CPs) are a complex family of contaminants. Lack of exposure data and an understanding of the fate of these chemicals in the environment affect our ability to reliably assess the human health risk associated with CP exposure. The present study focused on the evaluation of CP transfer from feed to eggs of laying hens exposed over 91 days. Laying hens were provided feed spiked with five technical mixtures of short-, medium- or long-chain CPs and featuring low or high...
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#2B. Le BizecH-Index: 28
Last. Gaud DervillyH-Index: 8
view all 3 authors...
Abstract Exposure to chemical hazards is a growing concern in today’s society, and it is of utmost interest to know the levels of exposure to chemicals and the risks associated with such exposure in order to implement effective health prevention strategies. Chemical risk analysis represents a complex and laborious task due to the large number of known substances, but also unknown compounds and emerging risks that must be addressed. In this challenging scenario, the study of metabolic perturbatio...
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#1Ronan CariouH-Index: 18
#2Paula Méndez-Fernandez (University of La Rochelle)H-Index: 12
Last. Gaud DervillyH-Index: 8
view all 9 authors...
To date, nontargeted analysis (NTA) of halogenated organic compounds in biota has mostly been performed using GC/MS-based instruments. We intended to broaden the spectrum of physicochemical propert...
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#1Alexander A. Aksenov (UM: University of Montana)H-Index: 25
#2Ivan Laponogov (Imperial College London)H-Index: 11
Last. Katherine N. Maloney (UM: University of Montana)H-Index: 1
view all 70 authors...
We engineered a machine learning approach, MSHub, to enable auto-deconvolution of gas chromatography-mass spectrometry (GC-MS) data. We then designed workflows to enable the community to store, process, share, annotate, compare and perform molecular networking of GC-MS data within the Global Natural Product Social (GNPS) Molecular Networking analysis platform. MSHub/GNPS performs auto-deconvolution of compound fragmentation patterns via unsupervised non-negative matrix factorization and quantifi...
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