Di Qin
Ocean University of China
PolysaccharideHistamine H1 receptorSelf-healing hydrogelsWarburg effectHistamineViscosityNuclear chemistryFlocculationHistamine receptorNanotechnologyMinimum inhibitory concentrationIntensive care medicineNanocarriersBiochemical engineeringChemistryMaterials scienceAlkali metalCrystallizationVolume (thermodynamics)ReuseAllergyMinimum bactericidal concentrationPsychological interventionINTAsthmaFish scaleNatural (archaeology)AntagonistIrritationBiocompatibilityImmunotherapyImmunogenic cell deathSelf-healingCancer vaccineBiomaterialCelluloseCetirizineStaphylococcus aureusChitosanAntibacterial activityUreaSolventKetotifenCancer immunotherapyImmune checkpointChitinDrug accumulationBiological propertyWound dressingNutrient brothMagnesium ionDemand marketCartilage repairMechanical propertyCell scaffoldWound managementAllergen avoidanceDrug releaseComputer scienceChemical engineeringTissue engineeringPharmacotherapyCancer researchPolymerBacteriaSodiumMagnesiumThermal stabilityMedicineNasal administrationZeta potentialDissolutionImmune systemPharmacology
10Publications
2H-index
22Citations
Publications 9
Newest
#1Mengjie Sun (Ocean University of China)H-Index: 6
#2Di Qin (Ocean University of China)H-Index: 2
Last. Ya Liu (Ocean University of China)H-Index: 21
view all 5 authors...
Allergic rhinitis (AR), histamine-mediated upper airway inflammatory disorder, is characterized by sneezing, itching, airway hyperreactivity, etc. Though it is clinically well-managed by non-invasive inhaled antihistamines, for example, ketotifen (KT, histamine release inhibitor) and cetirizine (CTZ, histamine receptor antagonist), inherent defects of short mucosal in situ retention, frequent administration resulting in irritation to mucosa, and lack of target-specific sequential release of dual...
Source
#1Shichao Bi (Ocean University of China)H-Index: 9
#2Fang Li (Ocean University of China)
Last. Xiguang Chen (Ocean University of China)H-Index: 61
view all 7 authors...
Abstract Chitin, the nitrogen-containing polysaccharide in nature and reserves second only to cellulose, has demonstrated potential application value in multiple fields. However, under the background of various environmental problems caused by the excessive use of petroleum-based polymers, the utilization rate of this eco-friendly and renewable natural polymer is far from reaching a reasonable level. Therefore, researches on the green dissolution system of chitin and the preparation method of fu...
Source
#1Shichao Bi (Ocean University of China)H-Index: 9
#2Mengyang Wang (Ocean University of China)H-Index: 2
Last. Xiguang Chen (Ocean University of China)H-Index: 61
view all 6 authors...
Source
#1Mengyang Wang (Ocean University of China)H-Index: 2
#2Bi ShichaoH-Index: 1
Last. Xiguang Chen (Ocean University of China)H-Index: 61
view all 8 authors...
Abstract In the present research, nutrient broth (NB) medium was identified to be able to neutralize the antibacterial activity of chitosan and its derivatives. Therefore, an improved test method independent of NB medium was proposed to precisely quantify the antibacterial effectiveness and efficiency of chitosan. The minimum bactericidal concentration (MBC) of chitosan was 60 μg mL−1 against S. aureus and E. coli, and 0.01 % (w/v) chitosan could kill 100 % of bacteria within 3 min. From another...
2 CitationsSource
#1Mengyang Wang (Ocean University of China)H-Index: 2
#2Shichao BiH-Index: 9
Last. Xiguang Chen (Ocean University of China)H-Index: 61
view all 6 authors...
Abstract In the present research, an optimized liquid medium which had no neutralizing effect to chitosan was developed. Moreover, magnesium chloride (MgCl2) was identified to be able to absolutely neutralize the antibacterial activity of chitosan and its derivatives. Took the two results together, the minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC) of chitosan were precisely quantified through a further improved method based on the optimized medium and the re...
1 CitationsSource
Allergy, IgE-mediated inflammatory disorders including allergic rhinitis, asthma, and conjunctivitis, affects billions of people worldwide. Conventional means of allergy management include allergen avoidance, pharmacotherapy, and emerging therapies. Among them, chemotherapeutant intake via oral, intravenous, and intranasal routes is always the most common mean. Although current pharmacotherapy exhibit splendid anti-allergic effects, short in situ retention, low bioavailability, and systemic side...
Source
#1Cong-Shan Yuan (Ocean University of China)H-Index: 1
#2Zhenwei Deng (Ocean University of China)H-Index: 1
Last. Ya Liu (Ocean University of China)H-Index: 21
view all 6 authors...
Abstract The past several years have witnessed the blooming of emerging immunotherapy, as well as their therapeutic potential in remodeling the immune system. Nevertheless, with the development of biological mechanisms in oncology, it has been demonstrated that hypoxic tumor microenvironment (TME) seriously impairs the therapeutic outcomes of immunotherapy. Hypoxia, caused by Warburg effect and insufficient oxygen delivery, has been considered as a primary construction element of TME and drawn t...
Source
#1Andi Zhang (Ocean University of China)H-Index: 2
#2Ya Liu (Ocean University of China)H-Index: 21
Last. Xiguang Chen (Ocean University of China)H-Index: 61
view all 6 authors...
Abstract Wound management has attracted significant interest in view of the broad demand market. Dressings are playing crucial roles in wounds management because they can protect the wound from external infection, and accelerate the healing process. Among the various available dressing materials, hydrogels have appealed increasing attention for their tunable chemical, physical and biological properties, and three-dimensional cross-linked polymer networks which can absorb and retain large amount ...
16 CitationsSource
#1Shichao Bi (Ocean University of China)H-Index: 9
#2Mengyang Wang (Ocean University of China)H-Index: 2
Last. Xiguang Chen (Ocean University of China)H-Index: 61
view all 6 authors...
Alkali/urea, a green dissolution system for chitosan, have been widely used in preparation of chitosan-derived materials. However, there are no related reports detail the structure stability and biocompatibility of chitosan in alkali/urea, which are important for its large-scale application. In this work, chitosan was dissolved in KOH/urea solution and stored at different temperature for different time. The structure, viscosity, molecule weight (Mw), degree of deacetylation (DD), and biocompatib...
7 CitationsSource