Yukinori Yoshii
Okayama University
Neutrophil extracellular trapsBlood proteinsCellular differentiationCellMedicinal chemistryPhagocytosisAntibody opsonizationReceptorChemistryChelationHistidine-rich glycoproteinHydroxyl radicalAntioxidantZymosanBalanced salt solutionRetinoic acidExtracellularCIRCULATORY FAILUREDivalent metal ionsFunctional evaluationReactive oxygen speciesViability assayCell cultureCell biology
5Publications
3H-index
3Citations
Publications 5
Newest
#1Yohei TakahashiH-Index: 2
#2Hidenori WakeH-Index: 17
Last. Masahiro NishiboriH-Index: 51
view all 7 authors...
Histidine-rich glycoprotein (HRG) is a multifunctional plasma protein and maintains the homeostasis of blood cells and vascular endothelial cells. In the current study, we demonstrate that HRG and recombinant HRG concentration dependently induced the phagocytic activity of isolated human neutrophils against fluorescence-labeled Escherichia coli and Staphylococcus aureus through the stimulation of CLEC1A receptors, maintaining their spherical round shape. The phagocytosis-inducing effects of HRG ...
1 CitationsSource
#1Yukinori Yoshii (Okayama University)H-Index: 3
#2Hidenori Wake (Okayama University)H-Index: 17
Last. Masahiro Nishibori (Okayama University)H-Index: 51
view all 6 authors...
Background: Histidine-rich glycoprotein (HRG) treatment ameliorated the survival rate of septic mice by suppressing excess immunothrombus formation. Although such findings suggested that HRG may be one of the most useful drugs for sepsis, obtaining a stable experimental system to standardize the HRG drug product is difficult to achieve using neutrophils isolated from volunteers. This is due to the short survival time and individual differences of human neutrophils. In the present study, we deter...
1 CitationsSource
#1Hidenori Wake (Okayama University)H-Index: 17
#2Yohei Takahashi (Okayama University)H-Index: 2
Last. Masahiro Nishibori (Okayama University)H-Index: 51
view all 8 authors...
Sepsis is caused by infections associated with life-threatening multiple organ failure (MOF). Septic MOF appears to be closely related to circulatory failure due to immunothrombosis. This process i...
2 CitationsSource
#1Yohei Takahashi (Okayama University)H-Index: 2
#2Hidenori Wake (Okayama University)H-Index: 17
Last. Masahiro Nishibori (Okayama University)H-Index: 51
view all 6 authors...
Source
#1Yukinori Yoshii (Okayama University)H-Index: 3
#2Hidenori Wake (Okayama University)H-Index: 17
Last. Masahiro Nishibori (Okayama University)H-Index: 51
view all 7 authors...
Source