Pierre C. Dromel
Harvard University
Induced pluripotent stem cellPleomorphism (cytology)Embryonic stem cellRetinal regenerationChemistryProgenitor cellIn vivoKOSRRetinaGliomaNeurofibromatosisBrain tumorRetinalOptic nerveRetinal degenerationStem cellOxygen tensionViability assayMedicineCell biology
5Publications
1H-index
1Citations
Publications 4
Newest
#1Pierre C. Dromel (MIT: Massachusetts Institute of Technology)H-Index: 1
#2Deepti SinghH-Index: 14
Last. Michael J. YoungH-Index: 43
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#1Deepti Singh (Harvard University)H-Index: 14
#2Pierre C. Dromel (MIT: Massachusetts Institute of Technology)H-Index: 1
Last. Michael J. Young (Harvard University)H-Index: 43
view all 5 authors...
The optic pathway glioma (OPG) is a slow-growing brain tumor that arises along the optic nerve or its downstream connections and causing vision to gradually worsen with time. This tumor forms in ch...
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#1Pierre C. Dromel (MIT: Massachusetts Institute of Technology)H-Index: 1
#2Deepti Singh (MEE: Massachusetts Eye and Ear Infirmary)H-Index: 14
Last. Michael J. Young (MEE: Massachusetts Eye and Ear Infirmary)H-Index: 43
view all 6 authors...
Abstract Many progenitor and stem cell-based therapies in pre-clinical development and in clinical trial have failed to achieve desired outcomes, in part, due to: low cell viability; dispersion of cells from the injection site; and/or failure of the cells to differentiate and engraft into host tissue. These problems may be exacerbated by the elevated shear stress applied to the cells as they pass through a small-bore needle. Our supposition is that these issues can be mitigated by replacing the ...
1 CitationsSource
#1Deepti Singh (Harvard University)H-Index: 14
#2Pierre C. Dromel (MIT: Massachusetts Institute of Technology)H-Index: 1
Last. Michael J. Young (Harvard University)H-Index: 43
view all 3 authors...
Using stem and progenitor cells to treat retinal disorders holds great promise. Using defined culture conditions to maintain the desires phenotype is of utmost clinical importance. We cultured human retinal progenitor cells (hRPCs) in different conditions: such as normoxia (20% oxygen), and hypoxia (5% oxygen) with and without knock-out serum replacement (KOSR) to evaluate its effect on these cells. KOSR is known nutrient supplement often used to replace bovine serum for culturing embryonic or p...
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