Zhen Li
Guangzhou University of Chinese Medicine
Stress granulemicroRNAGene knockdownChemistryApoptosisMesenchymal stem cellIn vivoStimulationNeuroprotectionMechanism of actionWestern blotLactate dehydrogenaseMetaboliteAntioxidantFlavonolsQuercetinTandem mass spectrometryMethylationViability assayIschemiaFlow cytometryBiochemistryMethyltransferaseCell biology
4Publications
2H-index
12Citations
Publications 4
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#1Shanyu YeH-Index: 3
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#1Wenwen Si (Guangzhou University of Chinese Medicine)H-Index: 4
#2Zhen Li (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Meiling Zhu (Guangzhou University of Chinese Medicine)H-Index: 4
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As a sensitive cold-shock protein, RNA binding protein motif 3 (RBM3) exhibits a neuroprotective function in the condition of brain injury. However, how RBM3 is involved in acute ischemic stroke by affecting stress granules (SGs) remains unclear. Here, we established an oxygen-glucose deprivation/reperfusion (OGD/R) model in rat primary cortical neurons and PC12 cells to explore the potential mechanism between RBM3 and SG formation in acute ischemic/reperfusion (I/R) condition. The immunofluores...
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#1Wenwen Si (Guangzhou University of Chinese Medicine)H-Index: 4
#2Yi Li (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Meiling ZhuH-Index: 4
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The modification of methyltransferase-like (METTL) enzymes plays important roles in various cellular responses by regulating microRNA expression. However, how m6A modification is involved in stress granule (SG) formation in the early stage of acute ischemic stroke by affecting the biogenesis processing of microRNAs remains unclear. Here, we established a middle cerebral artery occlusion (MCAO) model in rats and an oxygen-glucose deprivation/reperfusion (OGD/R) model in primary cortical neurons a...
7 CitationsSource
#1Xican Li (Guangzhou University of Chinese Medicine)H-Index: 19
#2Jingyuan Zeng (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
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In this study, the anti-ferroptosis effects of catecholic flavonol quercetin and its metabolite quercetin Diels-Alder anti-dimer (QDAD) were studied using an erastin-treated bone marrow-derived mesenchymal stem cell (bmMSCs) model. Quercetin exhibited higher anti-ferroptosis levels than QDAD, as indicated by 4,4-difluoro-5-(4-phenyl-1,3-butadienyl)-4-bora-3a,4a-diaza-s-indacene-3-undecanoic acid (C11-BODIPY), 2′,7′-dichlorodihydrofluoroscein diacetate (H2DCFDA), lactate dehydrogenase (LDH) relea...
13 CitationsSource