Annahita Sedghi
Dresden University of Technology
Internal medicinePathologyCardiologyInfection controlRandomized controlled trialCohort studyObservational studyVasomotorBiofeedbackCochrane LibraryAutonomic nervous systemSynucleinopathiesSudomotorDiseaseParkinson's diseaseSkin biopsyAlpha-synucleinCoronavirus disease 2019 (COVID-19)In patientConfidence intervalStrokeClinical trialHeart rate variabilityMedicineRelative riskPandemicMeta-analysis
11Publications
5H-index
38Citations
Publications 12
Newest
#1Alberto Farina (International University, Cambodia)
#2Federico Moro (Mario Negri Institute for Pharmacological Research)H-Index: 6
Last. Timo Siepmann (International University, Cambodia)H-Index: 17
view all 6 authors...
We aimed to evaluate the quality of clinical evidence that substantiated approval of cancer medicines by the European Medicines Agency (EMA) in the last decade. We performed a systematic review and data synthesis of EMA documents in agreement with PRISMA guidelines. We included the European Public Assessment Reports, Summaries of Product Characteristics, and published randomized controlled trials (RCTs) on anti-cancer drugs approved by EMA from 2010 to 2019, and excluded drugs not indicated for ...
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#1Annahita Sedghi (TUD: Dresden University of Technology)H-Index: 5
#2Timo Siepmann (TUD: Dresden University of Technology)H-Index: 17
Last. Kristian Barlinn (TUD: Dresden University of Technology)H-Index: 21
view all 7 authors...
We aimed to assess how evidence-based stroke care changed over the two waves of the COVID-19 pandemic. We analyzed acute stroke patients admitted to a tertiary care hospital in Germany during the first (2 March 2020-9 June 2020) and second (23 September 2020-31 December 2020, 100 days each) infection waves. Stroke care performance indicators were compared among waves. A 25.2% decline of acute stroke admissions was noted during the second (n = 249) compared with the first (n = 333) wave of the pa...
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#1Kathrin Doppler (University of Würzburg)H-Index: 17
#2Elena Antelmi (UNIBO: University of Bologna)H-Index: 21
Last. Rocco Liguori (UNIBO: University of Bologna)H-Index: 56
view all 19 authors...
Abstract Objective /methods: Phosphorylated alpha-synuclein (p-syn) in dermal nerves of patients with isolated REM sleep behavior disorder (iRBD) is detectable by immunofluorescence-labeling. Skin-biopsy-p-syn-positivity was recently postulated to be a prodromal marker of Parkinson’s disease (PD) or related synucleinopathies. Here, we provide two-to four-year clinical and skin biopsy follow-up data of 33 iRBD patients, whose skin biopsy findings at baseline were reported in 2017. Results Follow-...
1 CitationsSource
#1Timo SiepmannH-Index: 17
#2Annahita SedghiH-Index: 5
Last. Kristian BarlinnH-Index: 21
view all 21 authors...
Introduction: Recent studies linked coronavirus disease 2019 (COVID-19) to thromboembolic complications likely mediated by increased blood coagulability and inflammatory endothelial impairment. Obj...
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#1Timo Siepmann (TUD: Dresden University of Technology)H-Index: 17
#1Timo Siepmann (TUD: Dresden University of Technology)H-Index: 7
Last. Kristian Barlinn (TUD: Dresden University of Technology)H-Index: 21
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To determine whether a history of cerebrovascular disease (CVD) increases risk of severe coronavirus disease 2019 (COVID-19). In a retrospective multicenter study, we retrieved individual data from in-patients treated March 1 to April 15, 2020 from COVID-19 registries of three hospitals in Saxony, Germany. We also performed a systematic review and meta-analysis following PRISMA recommendations using PubMed, EMBASE, Cochrane Library databases and bibliographies of identified papers (last search o...
4 CitationsSource
#1Timo Siepmann (TUD: Dresden University of Technology)H-Index: 17
#1Timo Siepmann (TUD: Dresden University of Technology)H-Index: 7
Last. Kristian Barlinn (TUD: Dresden University of Technology)H-Index: 21
view all 21 authors...
BACKGROUND AND PURPOSE: Recent observations linked coronavirus disease 2019 (COVID-19) to thromboembolic complications possibly mediated by increased blood coagulability and inflammatory endothelial impairment. We aimed to define the risk of acute stroke in patients with severe and non-severe COVID-19. METHODS: We performed an observational, multicenter cohort study in four participating hospitals in Saxony, Germany to characterize consecutive patients with laboratory-confirmed COVID-19 who expe...
17 CitationsSource
#1Timo SiepmannH-Index: 17
#2Annahita SedghiH-Index: 5
Last. Kristian BarlinnH-Index: 11
view all 21 authors...
Introduction: Recent studies linked coronavirus disease 2019 (COVID-19) to thromboembolic complications likely mediated by increased blood coagulability and inflammatory endothelial impairment Objective: We aimed to assess the risk of acute stroke in patients with COVID-19 related to clinical severity of the disease Methods: We conducted an observational multicenter cohort study in four participating hospitals in Saxony, Germany to characterize consecutive patients with laboratory-confirmed COVI...
#1Timo Siepmann (TUD: Dresden University of Technology)H-Index: 17
#2Paulin Ohle (TUD: Dresden University of Technology)
Last. Kristian Barlinn (TUD: Dresden University of Technology)H-Index: 21
view all 11 authors...
Background: Neurocardiac dysfunction worsens clinical outcome and increases mortality in stroke survivors. We hypothesized that heart rate variability (HRV) biofeedback improves neurocardiac function by modulating autonomic nervous system activity after acute ischaemic stroke (AIS). Methods: We randomly allocated (1:1) 48 acute ischaemic stroke patients to receive nine sessions of HRV- or sham biofeedback over three days in addition to comprehensive stroke unit care. Before and after the interve...
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#1Kristian Barlinn (TUD: Dresden University of Technology)H-Index: 21
#2Timo Siepmann (TUD: Dresden University of Technology)H-Index: 17
Last. Volker Puetz (TUD: Dresden University of Technology)H-Index: 4
view all 13 authors...
Objective Stroke patients are thought to be at increased risk of Coronavirus Disease 2019 (COVID-19) To evaluate yield of universal laboratory testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in acute stroke patients and its impact on hyperacute stroke care Methods Between weeks 14 and 18 in 2020, a protected code stroke protocol including infection control screening and laboratory testing for SARS-CoV-2 was prospectively implemented for all code stroke patients upon arri...
5 CitationsSource
#1Mido Max Hijazi (TUD: Dresden University of Technology)H-Index: 3
#2Sylvia J. BuchmannH-Index: 5
Last. Timo Siepmann (TUD: Dresden University of Technology)H-Index: 17
view all 7 authors...
Cutaneous autonomic small nerve fibers encompass unmyelinated C-fibers and thinly myelinated Aδ-fibers, which innervate dermal vessels (vasomotor fibers), sweat glands (sudomotor fibers), and hair follicles (pilomotor fibers). Analysis of their integrity can capture early pathology in autonomic neuropathies such as diabetic autonomic neuropathy or peripheral nerve inflammation due to infectious and autoimmune diseases. Furthermore, intraneural deposition of alpha-synuclein in synucleinopathies s...
6 CitationsSource