Jingyuan Zeng
Guangzhou University of Chinese Medicine
ChemistryMesenchymal stem cellMechanism of actionLactate dehydrogenaseMetaboliteAntioxidantFlavonolsQuercetinTandem mass spectrometryBiochemistry
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#1Xican Li (Guangzhou University of Chinese Medicine)H-Index: 19
#2Jingyuan Zeng (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
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In this study, the anti-ferroptosis effects of catecholic flavonol quercetin and its metabolite quercetin Diels-Alder anti-dimer (QDAD) were studied using an erastin-treated bone marrow-derived mesenchymal stem cell (bmMSCs) model. Quercetin exhibited higher anti-ferroptosis levels than QDAD, as indicated by 4,4-difluoro-5-(4-phenyl-1,3-butadienyl)-4-bora-3a,4a-diaza-s-indacene-3-undecanoic acid (C11-BODIPY), 2′,7′-dichlorodihydrofluoroscein diacetate (H2DCFDA), lactate dehydrogenase (LDH) relea...
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