Gabriella Wahler
Rutgers University
Environmental chemistryArtPathologyDNA damageMolecular biologyMasson's trichrome stainControlled releaseGlutathione reductaseChemistrySolid lipid nanoparticleHeat shock proteinIn vivoSuperoxide dismutaseOxidative stressInflammationMucin 2DermisAntioxidantCurcuminStratum corneumWound healingEpidermisPhosphorylated Histone H2AXColon inflammationReticular DermisFood supplyMercury pollutionFat dietMale miceIndustrial pollutionFish consumptionIntestinal mucusCollagen networkPapillary dermisHuman exposureInorganic mercuryWheel runningHomogenization (biology)PhysiologyChromatographyGlutathioneGut floraMercury (element)MedicineEpidermis (botany)Transepidermal water loss
5Publications
1H-index
1Citations
Publications 5
Newest
#2Suneel KumarH-Index: 17
Last. Indu Pal KaurH-Index: 40
view all 17 authors...
The study aims to develop high drug-loaded (about 15% lipid matrix) curcumin solid lipid nanoparticles (CSLNs) for wound healing. CSLNs prepared by hot, high-pressure homogenization, without using organic solvents, were optimized using the Taguchi design followed by the central composite design. The optimized CSLNs exhibited a high assay/drug content (0.6% w/w), solubility (6 × 105 times), and EE (75%) with a particle size < 200 nm (PDI—0.143). The CSLNs were safe (in vitro and in vivo), photost...
Source
#1Jeffrey D. Laskin (RU: Rutgers University)H-Index: 69
#2Gabriella Wahler (RU: Rutgers University)H-Index: 1
Last. Laurie B. Joseph (RU: Rutgers University)H-Index: 12
view all 7 authors...
Abstract Sulfur mustard (SM), a dermal vesicant that has been used in chemical warfare, causes inflammation, edema and epidermal erosions depending on the dose and time following exposure. Herein, a minipig model was used to characterize wound healing following dermal exposure to SM. Saturated SM vapor caps were placed on the dorsal flanks of 3-month-old male Gottingen minipigs for 30 min. After 48 h the control and SM wounded sites were debrided daily for 7 days with wet to wet saline gauze soa...
1 CitationsSource
#1Gabriella Wahler (RU: Rutgers University)H-Index: 1
#2Diane E. Heck (NYMC: New York Medical College)H-Index: 4
Last. Laurie B. Joseph (RU: Rutgers University)H-Index: 12
view all 6 authors...
Abstract Nitrogen mustard (NM) is a highly reactive bifunctional alkylating agent that induces inflammation, edema and blistering in skin. An important mechanism mediating the action of NM and related mustards is oxidative stress. In these studies a modified murine patch-test model was used to analyze DNA damage and the antioxidant/stress response following NM exposure in isolated epidermis. NM (20 μmol) was applied to glass microfiber filters affixed to a shaved dorsal region of skin of CD-1 mi...
1 CitationsSource
#1Diane E. Heck (NYMC: New York Medical College)H-Index: 38
#2Laurie B. Joseph (RU: Rutgers University)H-Index: 12
Last. Hong-Duck KimH-Index: 14
view all 7 authors...
Both inorganic mercury and organic mercury compounds, including methyl mercury and ethyl mercury, are noxious pollutants known to cause deleterious neurological and cardiovascular effects in humans and profoundly affect the brains and development of infants and children (for review see Bernhoft RA. J Environ Public Health, 2012; Jung-Duck Park, Wei Zheng. J Prev Med Public Health. 45(6):344–352, 2012; Charles TD, Robert PM, Hing MC, Daniel JJ, Nicola P. J Prev Med Public Health 45(6):344–352, 20...
Source
#1Paul J. Wisniewski (RU: Rutgers University)H-Index: 4
#2Gabriella Wahler (RU: Rutgers University)H-Index: 1
Last. Sara C. Campbell (RU: Rutgers University)H-Index: 13
view all 6 authors...
The influence of diet and exercise on intestinal mucus and the spatial organisation of the microbiota is poorly understood. Though, it has been observed that the spatial organisation of the microbi...
Source